Evidence map›Paper›PMID 38445264›Full record

ArticleFrontiers in neurology2024

Sex differences in functional outcomes of intravenous thrombolysis among patients with lacunar stroke.

Patrizia Wueger, Roberta Noseda, Alberto Pagnamenta, Giovanni Bianco, David Seiffge, Patrik Michel, Krassen Nedeltchev, Leo Bonati, Georg Kägi, Julien Niederhauser and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 17 institutions in 1 country.

Patrizia Wueger *Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland.
Roberta Noseda *Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, Lugano, Switzerland.
Alberto PagnamentaClinical Trial Unit, Ente Ospedaliero Cantonale, Lugano, Switzerland.
Giovanni BiancoNeurocentre of Southern Switzerland, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale, Lugano, Switzerland.
David SeiffgeDepartment of Neurology, University Hospital Bern, Bern, Switzerland.
Patrik MichelStroke Center, Neurology Service, Lausanne University Hospital, Lausanne, Switzerland.
Krassen NedeltchevDepartment of Neurology, Kantonsspital Aarau, Aarau, Switzerland.
Leo BonatiDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Georg KägiDepartment of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Julien NiederhauserStroke Unit, Hopital Nyon, Nyon, Switzerland.
Thomas NyffelerCenter of Neurology and Neurorehabilitation, Luzerner Kantonsspital, Luzern, Switzerland.
Andreas LuftDepartment of Neurology, Universitätsspital Zürich, Zürich, Switzerland.
Susanne WegenerDepartment of Neurology, Universitätsspital Zürich, Zürich, Switzerland.
Ludwig ScheloskyDivision of Neurology, Kantonsspital Münsterlingen, Münsterlingen, Switzerland.
Friedrich MedlinDivision of Neurology, HFR Fribourg, Stroke Unit, Fribourg, Switzerland.
Biljana RodicDepartment of Neurology, Kantonsspital Winterthur, Winterthur, Switzerland.
Nils PetersDepartment of Neurology and Stroke Center, Hirslanden Hospital, Zurich, Switzerland.
Susanne RenaudDivision of Neurology, Pourtalès Hospital, Neuchatel, Switzerland.
Marie Luise MonoStroke Unit, Stadtspital Waid und Triemli, Zürich, Switzerland.
Emmanuel CarreraDepartment of Neurology, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
Urs FischerDepartment of Neurology, University Hospital Bern, Bern, Switzerland.
Gian Marco De MarchisDepartment of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Carlo W CeredaFaculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland.
Ente Ospedaliero Cantonale · CHKantonsspital St. Gallen · CHUniversità della Svizzera italiana · CHUniversity Hospital of Bern · CHUniversity Hospital of Zurich · CHGymnase de Nyon · CHHôpital Beau-Séjour · CHHospital Neuchâtel · CHKantonsspital Aarau · CHKantonsspital Münsterlingen · CHKantonsspital Winterthur · CHKlinik Hirslanden · CHLuzerner Kantonsspital · CHStadtspital Waid · CHUniversity Hospital of Basel · CHUniversity of Geneva · CHUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aimed to assess if there are sex differences in the functional outcome of intravenous thrombolysis (IVT) among patients with lacunar stroke (LS). Methods: Consecutive patients admitted from 1 January 2014 to 31 January 2020 to hospitals participating in the Swiss Stroke Registry presenting with LS and treated with IVT were included. The study population was then divided into two groups based on patient sex, and a multivariable ordinal logistic regression analysis was performed to uncover sex differences in the modified Rankin Scale (mRS) score at 90 days after stroke. Results: A total of 413 patients with LS were treated with IVT: 177 (42.9%) women and 236 (57.1%) men. Women were older than men (median age 74 years, 25th-75th percentiles 67-84 years versus 70 years, 25th-75th percentiles 60-80 years, value of p 0.001) and, after adjustment for meaningful variables, showed more frequently increased odds of a higher mRS score at 90 days after stroke (adjusted odds ratio 1.49, 95% confidence interval 1.01-2.19, value of p 0.044). Conclusion: This study showed that female sex increased the odds of a worse functional response to IVT in patients with LS. Future studies should further elucidate the mechanisms underlying such sex differences.

Indexed as

cohort studyfunctional outcomeintravenous thrombolysislacunar strokesex differences

Identifiers

PMID38445264
PMCPMC10914024
OpenAlexW4391784457

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.