Evidence map›Paper›PMID 38445239›Full record

ArticleIEEE open journal of engineering in medicine and biology2024

Simulation of Image-Guided Microwave Ablation Therapy Using a Digital Twin Computational Model.

Frankangel Servin, Jarrod A Collins, Jon S Heiselman, Katherine C Frederick-Dyer, Virginia B Planz, Sunil K Geevarghese, Daniel B Brown, William R Jarnagin, Michael I Miga

Open access · goldAbstract read
In one paragraph

Article in IEEE open journal of engineering in medicine and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 24 citations in OpenAlex.

  1. [Ultrasound technology's new application in the diagnosis and treatment of liver cancer].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  2. Personalization of liver microwave ablation simulation.International journal of computer assisted radiology and surgery · 2026
    Article
  3. A digital twin for microwave liver treatment replanning.International journal of computer assisted radiology and surgery · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Frankangel ServinDepartment of Biomedical EngineeringVanderbilt University Nashville TN 37235 USA.ORCID https://orcid.org/0009-0008-8511-0052
Jarrod A CollinsDepartment of Biomedical EngineeringVanderbilt University Nashville TN 37235 USA.ORCID https://orcid.org/0000-0003-4388-1779
Jon S HeiselmanDepartment of Biomedical EngineeringVanderbilt University Nashville TN 37235 USA.ORCID https://orcid.org/0000-0002-4414-8846
Katherine C Frederick-DyerDepartment of RadiologyVanderbilt University Medical Center Nashville TN 37235 USA.ORCID https://orcid.org/0000-0002-3281-1452
Virginia B PlanzDepartment of RadiologyVanderbilt University Medical Center Nashville TN 37235 USA.ORCID https://orcid.org/0000-0002-8365-2324
Sunil K GeevargheseDepartment of SurgeryVanderbilt University Medical Center Nashville TN 37235 USA.ORCID https://orcid.org/0000-0001-6356-0310
Daniel B BrownDepartment of RadiologyVanderbilt University Medical Center Nashville TN 37235 USA.
William R JarnaginDepartment of Surgery, Hepatopancreatobiliary ServiceMemorial Sloan Kettering Cancer Center New York NY 10065 USA.ORCID https://orcid.org/0000-0002-1635-5768
Michael I MigaDepartment of Biomedical EngineeringVanderbilt University Nashville TN 37235 USA.ORCID https://orcid.org/0000-0002-0694-9765
Vanderbilt University Medical Center · USVanderbilt University · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Deformation Corrected Image Guided Laparoscopic Liver SurgeryR01EB027498 · NIBIB · VANDERBILT UNIVERSITY · PI JARNAGIN, WILLIAM ROBERT, MIGA, MICHAEL IAN · 2019 to 2022
$2.5M
Training Program for Innovative Engineering Research in Surgery and InterventionT32EB021937 · NIBIB · VANDERBILT UNIVERSITY · PI Dario J Englot, Michael Ian Miga · 2016 to 2026
$2.3M
NCI NIH HHS P30 CA008748NIBIB NIH HHS R01 EB027498NIBIB NIH HHS T32 EB021937
6 · The paper itself

Abstract

Emerging computational tools such as healthcare digital twin modeling are enabling the creation of patient-specific surgical planning, including microwave ablation to treat primary and secondary liver cancers. Healthcare digital twins (DTs) are anatomically one-to-one biophysical models constructed from structural, functional, and biomarker-based imaging data to simulate patient-specific therapies and guide clinical decision-making. In microwave ablation (MWA), tissue-specific factors including tissue perfusion, hepatic steatosis, and fibrosis affect therapeutic extent, but current thermal dosing guidelines do not account for these parameters. This study establishes an MR imaging framework to construct three-dimensional biophysical digital twins to predict ablation delivery in livers with 5 levels of fat content in the presence of a tumor. Four microwave antenna placement strategies were considered, and simulated microwave ablations were then performed using 915 MHz and 2450 MHz antennae in

Indexed as

Computational modeldigital twinfatty liver diseasefinite elementliver cancermicrowave ablation

Identifiers

PMID38445239
PMCPMC10914207
OpenAlexW4390285285

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.