ReviewFrontiers in oral health2024
Effect of different forms of tobacco on the oral microbiome in healthy adults: a systematic review.
Review in Frontiers in oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- The association between self-reported vaping and the human oral microbiome: a systematic review.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Pooled it
- Does Probiotic Therapy Improve Periodontal Treatment Outcomes in Smoking Patients? A Systematic Review of Randomized Clinical Trials.Probiotics and antimicrobial proteins · 2026Pooled it
- Physical Activity, Dietary Inflammatory Potential, and Depressive Symptoms Among U.S. Adults: The Potential Contribution of Oral Microbial Dysbiosis.Healthcare (Basel, Switzerland) · 2026Article
- Influence of heat-non-burn tobacco aerosol on the microbiome of biofilm from human whole saliva bacteria in vitro.Clinical oral investigations · 2026Article
- Role of oral bacteria composition and functional gene profiles in respiratory diseases.BMJ open respiratory research · 2026Article
- Diagnostic modulation of subgingival proteomic biomarkers by age and smoking habits in periodontitis.Journal of periodontology · 2026Article
- Tobacco-Induced Oral Dysbiosis and Microbial Shifts: A Narrative Review of Their Role in Systemic Inflammation and Disease.Microorganisms · 2026Review
- Shaping the Female Microbiome: A Review of Lifestyle Factors Influencing the Vaginal, Gut, Oral, and Skin Microenvironments.Microbial ecology · 2026Review
- Tobacco-derived particulates and the periodontal axis: Distinct cytotoxic and stress-related mechanisms in human gingival fibroblasts.Scientific reports · 2026Article
- The Oral Microbiome and Systemic Health: Current Insights into the Mouth-Body Connection.Life (Basel, Switzerland) · 2026Review
- The association between oral microbiome diversity and rheumatoid arthritis: a nationwide cross-sectional study.Clinical rheumatology · 2026Article
- Crossroads of well-being: oral health, neurology, neuronutrition and healthy aging.Open medicine (Warsaw, Poland) · 2026Review
- Microbial dysbiosis and host-microbe interactions in proliferative verrucous leukoplakia: insights into carcinogenic potential.Archives of microbiology · 2025Review
- Impact of electronic cigarette use on the oral microbiome: a protocol for a systematic review of clinical studies.Systematic reviews · 2025Article
- The Effects of Electronic Cigarettes on Oral Microbiome and Metabolome in 3D Tissue-Engineered Models.International dental journal · 2025Article
- A comprehensive assessment of smokeless tobacco (Shammah) extract: unraveling the effects on hematological parameters, antioxidant defense mechanisms, and organ health in rats.Journal of molecular histology · 2025Article
- The Oral-Gut Microbiome-Brain Axis in Cognition.Microorganisms · 2025Review
- Change of oral microbiome diversity by smoking across different age groups.Frontiers in microbiology · 2025Article
- Human oral microbiome and its influence on mental health and brain disorders.AIMS microbiology · 2025Review
- Influence of nitrate-containing arugula juice on nitrate-reducing oral bacteria and periodontopathogens in smokers' biofilm.Frontiers in dental medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The study aimed to evaluate the impact of tobacco use on the composition and functions of the oral microbiome in healthy adult humans. Methods: We conducted a systematic search on PubMed, Web of Science, and Cinhal databases for literature published until 15 December 2023, to identify studies that have evaluated the oral microbiome with culture-independent next-generation techniques comparing the oral microbiome of tobacco users and non-users. The search followed the PECO format. The outcomes included changes in microbial diversity and abundance of microbial taxa. The quality assessment was performed using the Newcastle-Ottawa Scale (NOS) (PROSPERO ID CRD42022340151). Results: Out of 2,435 articles screened, 36 articles satisfied the eligibility criteria and were selected for full-text review. Despite differences in design, quality, and population characteristics, most studies reported an increase in bacterial diversity and richness in tobacco users. The most notable bacterial taxa enriched in users were Conclusion: Tobacco smoking influences oral microbial community harmony, and it shows a definitive shift towards a proinflammatory milieu. Heterogeneities were detected due to sampling and other methodological differences, emphasizing the need for greater quality research using standardized methods and reporting. Systematic Review Registration: CRD42022340151.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.