ArticleBrain communications2024
Dementia risk and thalamic nuclei volumetry in healthy midlife adults: the PREVENT Dementia study.
Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Toward reliable thalamic segmentation: an evaluation of automated methods for structural MRI.Brain structure & function · 2026Article
- A DERIVED RELAXATION CONTRAST FROM SYNTHETIC MRI FOR DETECTING NETWORK MICROSTRUCTURAL VULNERABILITY.bioRxiv : the preprint server for biology · 2026Article
- Atrophy patterns of deep gray matter nuclei in Alzheimer's disease and frontotemporal dementia.Journal of Alzheimer's disease : JAD · 2025Article
- APOE ε4-related differences in brain structure, function, and connectivity at midlife: A scoping review.The journal of prevention of Alzheimer's disease · 2025Article
- Hypothalamic volume, sleep, and APOE genotype in cognitively healthy adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Thalamus anatomy predicts cognitive performance and hippocampal atrophy in aging adults: a UK Biobank study.Brain communications · 2025Article
- [International journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A reduction in the volume of the thalamus and its nuclei has been reported in Alzheimer's disease, mild cognitive impairment and asymptomatic individuals with risk factors for early-onset Alzheimer's disease. Some studies have reported thalamic atrophy to occur prior to hippocampal atrophy, suggesting thalamic pathology may be an early sign of cognitive decline. We aimed to investigate volumetric differences in thalamic nuclei in middle-aged, cognitively unimpaired people with respect to dementia family history and apolipoprotein ε4 allele carriership and the relationship with cognition. Seven hundred participants aged 40-59 years were recruited into the PREVENT Dementia study. Individuals were stratified according to dementia risk (approximately half with and without parental dementia history). The subnuclei of the thalamus of 645 participants were segmented on T
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Registered trials
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