ReviewAustralian prescriber2024
Therapeutic inertia.
Review in Australian prescriber, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations of sarcopenia and sarcopenic obesity with hypertension: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Neurologists' Views on the Management of Uncontrolled Epilepsy in Spain: A Preliminary Survey.Neurology and therapy · 2026Article
- The Role of Neurologists in the Management of Uncontrolled Epilepsy in Spain: Opportunities for Optimization.Neurology and therapy · 2026Review
- Clinical inertia in cardiovascular risk management: prevalence, associated factors, and impact on outcomes of the OPM study.Journal of global health · 2026Article
- Clinical pharmacists' aspirations on prescribing in cardiology within an academic health system.Exploratory research in clinical and social pharmacy · 2026Article
- When Doing Nothing Feels Safer: A Multilevel Framework for Therapeutic Inertia in Psychiatry.Healthcare (Basel, Switzerland) · 2026Review
- Pharmacists' Management of Urinary Tract Infection Symptoms in Community Pharmacy: Counseling Practices and Attitudes Toward Antibiotic Therapy.Pharmacy (Basel, Switzerland) · 2026Article
- Drug Critical Limits for Urgent Physician Notification.Clinical pharmacology and therapeutics · 2026Article
- Overtreatment and therapeutic nihilism in chronic epilepsy: a call to action!Acta epileptologica · 2026Review
- Perspectives on the burden of drug-resistant epilepsy and treatment priorities: Findings from a multistakeholder survey.Epilepsia open · 2026Article
- Real-world management of tuberous sclerosis complex-associated renal angiomyolipomas: the impact of mTOR inhibitors.Clinical kidney journal · 2026Article
- Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis.Annals of clinical and translational neurology · 2026Review
- Observational
- Developing a Comprehensive Approach for Managing Cardiorenal Metabolic Diseases (CRMD) in Saudi Arabia: Thinking beyond Single Disease-Literature Review and Multidisciplinary Consensus Report.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026Review
- Therapeutic Inertia in Lipid-Lowering Treatment: A Narrative Review.Journal of clinical medicine · 2026Review
- Initial conceptual development of a pilot questionnaire for patient-perceived clinical inertia in chronic disease management: an exploratory study with a predominantly Peruvian sample.Frontiers in health services · 2026Article
- Therapeutic Adherence in Cardiovascular Diseases: Insights from the Patient and Physician-A Narrative Review.Advances in therapy · 2026Review
- Seizures beget more than seizures: Understanding the cellular, structural, individual and societal impact of seizures in epilepsy.Epilepsia open · 2025Review
- Therapeutic Inertia in an Insured Population with Type 2 Diabetes in the United States: A Retrospective Cohort Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- Iron Deficiency Treatment in Heart Failure-Challenges and Therapeutic Solutions.Journal of clinical medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Therapeutic inertia, sometimes referred to as clinical inertia, has been defined as failure to initiate or intensify therapy when therapeutic goals are not reached. Lack of initiation or intensification of treatment according to clinical guidelines has been linked to suboptimal control of a range of chronic conditions. Clinician factors contributing to therapeutic inertia include knowledge gaps; discomfort with uncertainty about the diagnosis, therapeutic target, or evidence; concerns about the safety of treatment intensification; and time constraints. Patient characteristics that may be associated with therapeutic inertia include male sex, older age, lower life expectancy, multiple comorbidities and clinical parameters that are close to target. There may be reasons other than therapeutic inertia that explain apparent undertreatment. Apparent inertia in prescribing may be accompanied by appropriate actions, such as provision of lifestyle advice or interventions to promote adherence to existing medication. Some patients choose not to intensify treatment. Interventions to reduce therapeutic inertia include access to evidence-based treatment guidelines and point-of-care tools, preferably integrated with clinical record systems; clinician education including educational visits; reminders; clinical audits with feedback and reflection on practice; shared decision-making; prompting by patients; and ambulatory or home monitoring (e.g. ambulatory blood pressure monitoring).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.