Evidence map›Paper›PMID 38444830›Full record

ArticleBone reports2024

Microvascular disease not type 2 diabetes is associated with increased cortical porosity: A study of cortical bone microstructure and intracortical vessel characteristics.

Maximilian T Löffler, Po-Hung Wu, Amir M Pirmoazen, Gabby B Joseph, Jay M Stewart, Isra Saeed, Jing Liu, Anne L Schafer, Ann V Schwartz, Thomas M Link and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Maximilian T LöfflerDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St, Suite 350, San Francisco, CA 94107, USA.
Po-Hung WuDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St, Suite 350, San Francisco, CA 94107, USA.
Amir M PirmoazenDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St, Suite 350, San Francisco, CA 94107, USA.
Gabby B JosephDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St, Suite 350, San Francisco, CA 94107, USA.
Jay M StewartDepartment of Ophthalmology, University of California, San Francisco, CA, USA.
Isra SaeedDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St, Suite 350, San Francisco, CA 94107, USA.
Jing LiuDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St, Suite 350, San Francisco, CA 94107, USA.
Anne L SchaferDepartment of Medicine, University of California, San Francisco, CA, USA.
Ann V SchwartzDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Thomas M LinkDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St, Suite 350, San Francisco, CA 94107, USA.
Galateia J KazakiaDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St, Suite 350, San Francisco, CA 94107, USA.
Berry (United States) · USUniversity of California, San Francisco · USUniversity Medical Center Freiburg · DE

Funding

Progression and etiology of cortical porosity in diabetic bone diseaseR01AR069670 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAZAKIA, GALATEIA J · 2017 to 2023
$2.9M
Determining the Biological Mechanisms of Pathological Cortical PorosityR01AR076159 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAZAKIA, GALATEIA J · 2020 to 2022
$863k
Visualizing Cortical Pore Space ConstituentsR03AR064004 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAZAKIA, GALATEIA J · 2013 to 2015
$186k
NIAMS NIH HHS R01 AR069670NIAMS NIH HHS R01 AR076159NIAMS NIH HHS R03 AR064004
6 · The paper itself

Abstract

Introduction: Fracture risk is elevated in type 2 diabetes (T2D) despite normal or even high bone mineral density (BMD). Microvascular disease (MVD) is a diabetic complication, but also associated with other diseases, for example chronic kidney disease. We hypothesize that increased fracture risk in T2D could be due to increased cortical porosity (Ct.Po) driven by expansion of the vascular network in MVD. The purpose of this study was to investigate associations of T2D and MVD with cortical microstructure and intracortical vessel parameters. Methods: The study group consisted of 75 participants (38 with T2D and 37 without T2D). High-resolution peripheral quantitative CT (HR-pQCT) and dynamic contrast-enhanced MRI (DCE-MRI) of the ultra-distal tibia were performed to assess cortical bone and intracortical vessels (outcomes). MVD was defined as ≥1 manifestation including neuropathy, nephropathy, or retinopathy based on clinical exams in all participants. Adjusted means of outcomes were compared between groups with/without T2D or between participants with/without MVD in both groups using linear regression models adjusting for age, sex, BMI, and T2D as applicable. Results: MVD was found in 21 (55 %) participants with T2D and in 9 (24 %) participants without T2D. In T2D, cortical pore diameter (Ct.Po.Dm) and diameter distribution (Ct.Po.Dm.SD) were significantly higher by 14.6 μm (3.6 %, 95 % confidence interval [CI]: 2.70, 26.5 μm, Conclusions: The presence of MVD, rather than T2D, was associated with increased cortical porosity. Increased porosity in MVD was coupled with a larger number of smaller vessels, which could indicate upregulation of neovascularization triggered by ischemia. It is unclear why higher variability and average diameters of pores in T2D were accompanied by larger vessels.

Indexed as

Cortical boneDynamic contrast-enhanced MRIHR-pQCTMicrovascular diseasePorosityType 2 diabetes

Identifiers

PMID38444830
PMCPMC10912053
OpenAlexW4392142166

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.