Evidence map›Paper›PMID 38444657›Full record

ArticleERJ open research2024

Sputum metagenomics of people with bronchiectasis.

Ilona Rosenboom, Ajith Thavarasa, Hollian Richardson, Merete B Long, Lutz Wiehlmann, Colin F Davenport, Amelia Shoemark, James D Chalmers, Burkhard Tümmler

Open access · goldAbstract read
In one paragraph

Article in ERJ open research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Frontiers in immunology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ilona RosenboomDepartment of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0003-2431-5042
Ajith ThavarasaDepartment of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Hollian RichardsonDivision of Molecular and Clinical Medicine, University of Dundee, Dundee, UK.
Merete B LongDivision of Molecular and Clinical Medicine, University of Dundee, Dundee, UK.
Lutz WiehlmannResearch Core Unit Genomics, Hannover Medical School, Hannover, Germany.
Colin F DavenportResearch Core Unit Genomics, Hannover Medical School, Hannover, Germany.
Amelia ShoemarkDivision of Molecular and Clinical Medicine, University of Dundee, Dundee, UK.ORCID https://orcid.org/0000-0001-7360-6060
James D ChalmersDivision of Molecular and Clinical Medicine, University of Dundee, Dundee, UK.
Burkhard TümmlerDepartment of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0002-2566-8758
Medizinische Hochschule Hannover · DEUniversity of Dundee · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The microbiota in the sputum of people with bronchiectasis has repeatedly been investigated in cohorts of different geographic origin, but so far has not been studied to the species level in comparison to control populations including healthy adults and smokers without lung disease. Methods: The microbial metagenome from sputa of 101 European Bronchiectasis Registry (EMBARC) study participants was examined by using whole-genome shotgun sequencing. Results: Our analysis of the metagenome of people with bronchiectasis revealed four clusters characterised by a predominance of Conclusion: The gradient of depletion of commensal taxa found in healthy airways is a key feature of bronchiectasis associated with disease severity.

Identifiers

PMID38444657
PMCPMC10910388
OpenAlexW4391845508

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.