Evidence map›Paper›PMID 38444609›Full record

ArticleiScience2024

Placental transfer dynamics and durability of maternal COVID-19 vaccine-induced antibodies in infants.

Paola A Lopez, Nadège Nziza, Tina Chen, Lydia L Shook, Madeleine D Burns, Stepan Demidkin, Olyvia Jasset, Babatunde Akinwunmi, Lael M Yonker, Kathryn J Gray and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Paola A LopezDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Nadège NzizaRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Tina ChenRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Lydia L ShookMassachusetts General Hospital, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Boston, MA 02114, USA.
Madeleine D BurnsMassachusetts General Hospital for Children, Department of Pediatric, Boston, MA 02114, USA.
Stepan DemidkinMassachusetts General Hospital, Vincent Center for Reproductive Biology, Boston, MA 02114, USA.
Olyvia JassetMassachusetts General Hospital, Vincent Center for Reproductive Biology, Boston, MA 02114, USA.
Babatunde AkinwunmiBrigham and Women's Hospital, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Boston, MA 02115, USA.
Lael M YonkerHarvard Medical School, Boston, MA 02115, USA.
Kathryn J GrayHarvard Medical School, Boston, MA 02115, USA.
Michal A ElovitzWomen's Biomedical Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Douglas A LauffenburgerDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Boris D JulgRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Andrea G EdlowMassachusetts General Hospital, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Boston, MA 02114, USA.
Harvard University · USBoston Children's Hospital · USBrigham and Women's Hospital · USMassachusetts General Hospital · USMassachusetts Institute of Technology · USRagon Institute of MGH, MIT and Harvard · USBiomedical Research Institute · US

Funding

Research Project 2 The pregnancy AdaptOMEU19AI167899 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DOUGLAS A LAUFFENBURGER · 2022 to 2026
$14.7M
Defining neutrophil pathobiology in pediatric Long COVIDR01HL173059 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Lael Yonker · 2024 to 2026
$2.4M
Mechanistically Disentangling the Infected, Inflamed LungK08HL143183 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI YONKER, LAEL · 2018 to 2022
$869k
NHLBI NIH HHS K08 HL143183NHLBI NIH HHS R01 HL173059NIAID NIH HHS U19 AI167899
6 · The paper itself

Abstract

Completion of a COVID-19 vaccination series during pregnancy effectively reduces COVID-19 hospitalization among infants less than 6 months of age. The dynamics of transplacental transfer of maternal vaccine-induced antibodies, and their persistence in infants at 2, 6, 9, and 12 months, have implications for new vaccine development and optimal timing of vaccine administration in pregnancy. We evaluated anti-COVID antibody IgG subclass, Fc-receptor binding profile, and activity against wild-type Spike and RBD plus five variants of concern (VOCs) in 153 serum samples from 100 infants. Maternal IgG1 and IgG3 responses persisted in 2- and 6-month infants to a greater extent than the other IgG subclasses, with high persistence of antibodies binding placental neonatal Fc-receptor and FcγR3A. Lowest persistence was observed against the Omicron RBD-specific region. Maternal vaccine timing, placental Fc-receptor binding capabilities, antibody subclass, fetal sex, and VOC all impact the persistence of antibodies in infants through 12 months of age.

Indexed as

Classification DescriptionHealth sciencesImmunologyMicrobiologyPediatrics

Identifiers

PMID38444609
PMCPMC10914478
OpenAlexW4391966988

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.