ReviewEClinicalMedicine2024
Exploring the need for reconsideration of trial design in perioperative outcomes research: a narrative review.
Review in EClinicalMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07598552 (Early Cognitive Changes in Patients Aged 70 Years or Older After Same-day Discharge Hip and Knee Arthroplasty), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Cognitive Changes in Patients Aged 70 Years or Older After Same-day Discharge Hip and Knee Arthroplasty: A Prospective Cohort Study
Who cites it
17 citing papers in PubMed.
- Integration of Precision Medicine into ERAS Pathways: A Conceptual Framework, Current Feasibility and Challenges.Journal of personalized medicine · 2026Review
- Review
- Clinical outcomes of immediate, 24-h, and 24-72-h laparoscopic cholecystectomy after endoscopic stone clearance: a matched cohort analysis.Surgical endoscopy · 2026Article
- Systematic and precise interventions for KRAS-mutant cancers.Experimental hematology & oncology · 2026Review
- Esketamine vs. sufentanil for anesthesia induction in elderly patients undergoing transbronchial lung biopsy (TBLB): effect on hemodynamic stability, airway reactivity, and oxygenation.BMC anesthesiology · 2026Article
- Interventions for iron deficiency with or without anaemia in visceral surgery: recommendations for future research.BJA open · 2026Article
- Observational
- Do we need rehabilitation after total knee arthroplasty? Evidence, uncertainty and the need for focus.Journal of experimental orthopaedics · 2026Article
- Comparison of short-segment vs. long-segment fixation in posterior osteotomy for kyphotic deformity: effects on postoperative alignment and complications.Frontiers in surgery · 2026Article
- Feasibility of a prospective multicenter observational study-is diabetes a risk factor in ERAS joint arthroplasty?Pilot and feasibility studies · 2025Article
- Preoperative activation of the renin-angiotensin system and myocardial injury in noncardiac surgery: exploratory mechanistic analysis of the SPACE randomised controlled trial.British journal of anaesthesia · 2025Article
- A critical approach to research on perioperative pain management.British journal of anaesthesia · 2025Article
- PBM and ERAS: mandatory bedfellows.Blood transfusion = Trasfusione del sangue · 2025Article
- Enhanced recovery after surgery protocols for minimally invasive treatment of Achilles tendon rupture: Prospective single-center randomized study.World journal of orthopedics · 2024Article
- ERAS pathways and ambulatory surgery can reduce the global surgical burden: Role of anaesthesiologists.Indian journal of anaesthesia · 2024Article
- High-dose glucocorticoids: improving outcomes of emergency laparotomy by reducing inflammation.The British journal of surgery · 2024Article
- Outcome improvement for anaemia and iron deficiency in ERAS hip and knee arthroplasty: a descriptive analysis.Perioperative medicine (London, England) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
"Enhanced recovery after surgery" is a multimodal effort to control perioperative pathophysiology and improve outcome. However, despite advances in perioperative care, postoperative complications and the need for hospitalisation and prolonged recovery continue to be challenging. This is further complicated by procedure-specific and patient-associated risk factors, given the increase in the number of elderly and frail patients with multiple comorbidities undergoing surgery. This paper is a critical assessment of current methodology for trials in perioperative medicine. We make a plea to reconsider the design of future interventional trials to improve surgical outcome, based upon studies of potentially effective interventions, but often without improvements in recovery. The complexity of perioperative pathophysiology necessitates a procedure- and patient-specific approach whenever outcome is assessed or interventions are planned. With improved understanding of perioperative pathophysiology, the way to improve outcomes looks promising, provided that knowledge and established enhanced recovery programmes are integrated in trial design. Funding: None.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.