Evidence map›Paper›PMID 38444174›Full record

ArticleGenes, brain, and behavior2024

Network-based analysis predicts interacting genetic modifiers from a meta-mapping study of spike-wave discharge in mice.

Montana Kay Lara, Jeffrey L Brabec, Amanda E Hernan, Rod C Scott, Anna L Tyler, J Matthew Mahoney

Open access · hybridAbstract read
In one paragraph

Article in Genes, brain, and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Montana Kay LaraDepartment of Neurological Sciences, University of Vermont, Burlington, Vermont, USA.ORCID 0000-0001-5810-4425
Jeffrey L BrabecDepartment of Neurological Sciences, University of Vermont, Burlington, Vermont, USA.
Amanda E HernanDepartment of Neurological Sciences, University of Vermont, Burlington, Vermont, USA.ORCID 0000-0003-4931-3481
Rod C ScottDivision of Neuroscience, Nemours Children's Health, Wilmington, Delaware, USA.
Anna L TylerThe Jackson Laboratory, Bar Harbor, Maine, USA.ORCID 0000-0001-8371-2377
J Matthew MahoneyDepartment of Neurological Sciences, University of Vermont, Burlington, Vermont, USA.ORCID 0000-0003-1425-5939
University of Vermont · USJackson Laboratory · USNemours Children's Health System · US

Funding

Zhao - Proj 2P20GM130454 · NIGMS · DARTMOUTH COLLEGE · PI Li Song · 2019 to 2026
$27.2M
Inferring Molecular Mechanisms of Complex Disease by Integrating Patterns of Epistasis with Functional Genomic NetworksR21LM012615 · NLM · JACKSON LABORATORY · PI MAHONEY, JOHN MATTHEW, TYLER, ANNA L. · 2018 to 2019
$423k
NIGMS NIH HHS 1P20 GM130454NIGMS NIH HHS P20 GM130454NLM NIH HHS R21 LM012615
6 · The paper itself

Abstract

Absence seizures are characterized by brief lapses in awareness accompanied by a hallmark spike-and-wave discharge (SWD) electroencephalographic pattern and are common to genetic generalized epilepsies (GGEs). While numerous genes have been associated with increased risk, including some Mendelian forms with a single causal allele, most cases of GGE are idiopathic and there are many unknown genetic modifiers of GGE influencing risk and severity. In a previous meta-mapping study, crosses between transgenic C57BL/6 and C3HeB/FeJ strains, each carrying one of three SWD-causing mutations (Gabrg2

Indexed as

Genome-Wide Association StudyPatient DischargeAllelesAnimalsHumansMiceMice, Inbred C3HMice, Inbred C57BLNAV1.6 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelScn8a protein, mouseepilepsyepistasisfunctional networksgenetic generalized epilepsygenetic modifiersmachine learningnetwork analysisnetwork-based functional predictionquantitative geneticsspike and wave discharge

Identifiers

PMID38444174
PMCPMC10915378
OpenAlexW4392516245

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.