Evidence map›Paper›PMID 38444160›Full record

ArticleBiophysical journal2024

Distinct potassium channel types in brain capillary pericytes.

Maria Sancho, Nicholas R Klug, Osama F Harraz, David Hill-Eubanks, Mark T Nelson

Open access · greenAbstract read
In one paragraph

Article in Biophysical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Pericyte Electrical Signalling and Brain Haemodynamics.Basic & clinical pharmacology & toxicology · 2025
    Review
  7. Article
  8. Pericytes in mouse heart.Frontiers in physiology · 2025
    Article
  9. Article
  10. Electrocalcium coupling in brain capillaries: Rapidly traveling electrical signals ignite local calcium signals.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. KProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Juggling potassium: A diverse set of KBiophysical journal · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 3 countries.

Maria SanchoDepartment of Pharmacology, University of Vermont, Burlington, Vermont; Department of Physiology, Faculty of Medicine, Complutense University of Madrid, Madrid, Spain. Electronic address: masanc75@ucm.es.
Nicholas R KlugDepartment of Pharmacology, University of Vermont, Burlington, Vermont.
Osama F HarrazDepartment of Pharmacology, University of Vermont, Burlington, Vermont; Vermont Center for Cardiovascular and Brain Health, Larner College of Medicine, University of Vermont, Burlington, Vermont.
David Hill-EubanksDepartment of Pharmacology, University of Vermont, Burlington, Vermont.
Mark T NelsonDepartment of Pharmacology, University of Vermont, Burlington, Vermont; Vermont Center for Cardiovascular and Brain Health, Larner College of Medicine, University of Vermont, Burlington, Vermont; Division of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom. Electronic address: mark.nelson@uvm.ed.
University of Vermont · US

Funding

Vermont Center for Cardiovascular and Brain HealthP20GM135007 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MARY CUSHMAN, MARK T NELSON · 2020 to 2026
$17.4M
Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and DiseaseR35HL140027 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2025
$6.3M
Ion Channel Dysfunction in Small Vessel Disease of the BrainR01NS110656 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2023
$2.6M
Endothelial Piezo1 channel and cerebral blood flow controlR01HL169681 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Osama F Harraz · 2023 to 2026
$2.3M
Lesions and loss of smooth muscle cells in brain underlies small vessel diseaseRF1NS128963 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JOUTEL, ANNE, NELSON, MARK T · 2022 to 2023
$2.2M
Brain capillary Piezo1 ion channels and blood flow regulation in Alzheimer’s DiseaseR21AG082193 · NIA · UNIVERSITY OF MIAMI CORAL GABLES · PI BRACKO, OLIVER, HARRAZ, OSAMA F · 2023 to 2024
$434k
Transitional Segment Hypercontractility in Small Vessel Disease with Intracerebral HemorrhageF32HL152576 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KLUG, NICHOLAS RYAN · 2020 to 2022
$201k
NHLBI NIH HHS F32 HL152576NHLBI NIH HHS R01 HL169681NHLBI NIH HHS R35 HL140027NIA NIH HHS R21 AG082193NIGMS NIH HHS P20 GM135007NINDS NIH HHS R01 NS110656NINDS NIH HHS RF1 NS128963
6 · The paper itself

Abstract

Capillaries, composed of electrically coupled endothelial cells and overlying pericytes, constitute the vast majority of blood vessels in the brain. The most arteriole-proximate three to four branches of the capillary bed are covered by α-actin-expressing, contractile pericytes. These mural cells have a distinctive morphology and express different markers compared with their smooth muscle cell (SMC) cousins but share similar excitation-coupling contraction machinery. Despite this similarity, pericytes are considerably more depolarized than SMCs at low intravascular pressures. We have recently shown that pericytes, such as SMCs, possess functional voltage-dependent Ca

Indexed as

BrainCapillariesPericytesAnimalsMiceMice, Inbred C57BLMice, TransgenicPotassium ChannelsPotassium Channels, Inwardly RectifyingPotassium ChannelsPotassium Channels, Inwardly Rectifying

Identifiers

PMID38444160
PMCPMC11309962
OpenAlexW4392764894

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.