Evidence map›Paper›PMID 38444158›Full record

ArticleBiophysical journal2024

Interaction with stomatin directs human proton channels into cholesterol-dependent membrane domains.

Artem G Ayuyan, Vladimir V Cherny, Gustavo Chaves, Boris Musset, Fredric S Cohen, Thomas E DeCoursey

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Modulators of the Human Voltage-Gated Proton Channel HPharmaceuticals (Basel, Switzerland) · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Artem G AyuyanDepartment of Physiology & Biophysics, Rush University, Chicago, Illinois. Electronic address: artem_ayuyan@rush.edu.
Vladimir V ChernyDepartment of Physiology & Biophysics, Rush University, Chicago, Illinois.
Gustavo ChavesInstitut für Physiologie, Pathophysiologie und Biophysik, CPPB, Paracelsus Medical University, Nürnberg, Germany.
Boris MussetInstitut für Physiologie, Pathophysiologie und Biophysik, CPPB, Paracelsus Medical University, Nürnberg, Germany.
Fredric S CohenDepartment of Physiology & Biophysics, Rush University, Chicago, Illinois.
Thomas E DeCourseyDepartment of Physiology & Biophysics, Rush University, Chicago, Illinois. Electronic address: tdecours@rush.edu.
Rush University · USParacelsus Medizinische Privatuniversität · DE

Funding

Biophysical Mechanisms of Cholesterol HomeostasisR01GM136777 · NIGMS · RUSH UNIVERSITY MEDICAL CENTER · PI COHEN, FREDRIC S · 2021 to 2024
$1.4M
Control Mechanisms of Human Voltage Gated Proton Channels, hHv1R35GM151963 · NIGMS · RUSH UNIVERSITY MEDICAL CENTER · PI THOMAS E DECOURSEY · 2024 to 2026
$1.3M
NIGMS NIH HHS R01 GM136777NIGMS NIH HHS R35 GM151963
6 · The paper itself

Abstract

Many membrane proteins are modulated by cholesterol. Here we report profound effects of cholesterol depletion and restoration on the human voltage-gated proton channel, hH

Indexed as

CholesterolIon ChannelsMembrane MicrodomainsMembrane ProteinsProtein BindingAnimalsHEK293 CellsHumansCholesterolHVCN1 protein, humanIon ChannelsMembrane ProteinsSTOM protein, human

Identifiers

PMID38444158
PMCPMC11700364
OpenAlexW4392764989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.