Evidence map›Paper›PMID 38444021›Full record

ArticleVirology journal2024

The POU-HD TFs impede the replication efficiency of several human papillomavirus genomes.

Martin Kala, Sofiya Babok, Nika Mikhailava, Marko Piirsoo, Alla Piirsoo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Martin KalaInstitute of Technology, University of Tartu, Tartu, Estonia.
Sofiya BabokInstitute of Technology, University of Tartu, Tartu, Estonia.
Nika MikhailavaInstitute of Technology, University of Tartu, Tartu, Estonia.
Marko PiirsooInstitute of Technology, University of Tartu, Tartu, Estonia.
Alla PiirsooInstitute of Technology, University of Tartu, Tartu, Estonia. alla.piirsoo@ut.ee.
University of Tartu · EE

Funding

Estonian Research Council PRG198University of Tartu PLTTI23911
6 · The paper itself

Abstract

Human papillomavirus (HPV) is a double-stranded DNA virus that infects cutaneous and mucosal epithelial cells. HPV replication initiates at the origin (ori), located within a noncoding region near the major early promoter. Only two viral proteins, E1 and E2, are essential for replication, with the host cell contributing other necessary factors. However, the role of host cell proteins in regulating HPV replication remains poorly understood. While several binding sites for cellular transcription factors (TFs), such as POU-HD proteins, have been mapped in the regulatory region, their functional importance is unclear. Some POU-HD TFs have been shown to influence replication in a system where E1 and E2 are provided exogenously. In this study, we investigated the impact of several POU-HD TFs on the replication of the HPV5, HPV11, and HPV18 genomes in U2OS cells and human primary keratinocytes. We demonstrated that OCT1, OCT6, BRN5A, and SKN1A are expressed in HPV host cells and that their overexpression inhibits HPV genome replication, whereas knocking down OCT1 had a positive effect. Using the replication-deficient HPV18-E1

Indexed as

Human Papillomavirus VirusesPapillomavirus InfectionsDNAHuman papillomavirus 18HumansPapillomaviridaeDNAHuman papillomavirusPOU-homeodomain transcription factorsReplicationTranscription

Identifiers

PMID38444021
PMCPMC10916165
OpenAlexW4392447277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.