Evidence map›Paper›PMID 38443860›Full record

ArticleBMC pulmonary medicine2024

Contribution of small airway inflammation to the development of COPD.

Li Li, Ying Gong, Dongni Hou, Yijun Song, Jing Bi, Miao Li, Junjie Han, Yuanlin Song, Jun She

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Small Airway Disease in Pre-COPD and Early COPD: Insights Into the Pulmonary "Silent Zone".International journal of chronic obstructive pulmonary disease · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Differential Clinical Significance of FENOJournal of asthma and allergy · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Li Li *Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China.
Ying Gong *Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China.
Dongni Hou *Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China.
Yijun Song *Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China.
Jing Bi *Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China.
Miao Li *Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China.
Junjie Han *Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China.
Yuanlin SongDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China. song.yuanlin@zs-hospital.sh.cn.
Jun SheDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China. she.jun@zs-hospital.sh.cn.

Funding

CATECHOLAMINES AND REPRODUCTIVE AGINGR01AG002021 · NIA · UNIVERSITY OF FLORIDA · PI SIMPKINS, JAMES W. · 1985 to 1990
–
National key R&D plan 2020YFC2003700Science and Technology Commission of Shanghai Municipality 20DZ2261200Shanghai Municipal Key Clinical Specialty shslczdzk02201The Construction of Multidisciplinary Cooperative Diagnosis and Treatment for Severe Pneumonia W2020-013The Mechanisms of Antibiotic Resistance in Severe Pneumonia Treated with Traditional Chinese and Western Medicine Number: ZY (2021-2023)-0207-01
6 · The paper itself

Abstract

backgroundLittle attention has been paid to the pathophysiological changes in the natural history of chronic obstructive pulmonary disease (COPD). The destructions of the small airways were visualized on thoracic micro-computed tomography scan. We investigated whether small airway inflammation (SAI) was the risk for the development of COPD.

methodsA total of 1062 patients were enrolled and analyzed in the study. The partitioned airway inflammation was determined by exhaled nitric oxide (NO) of FnNO, FeNO

resultsExhaled NO levels (FnNO, FeNO

conclusionThe complete airway inflammations were shown in COPD, whereas SAI was the main risk factor for the development of COPD, which might relate to eosinophil and basophil levels.

Indexed as

Bronchitis, ChronicPulmonary Disease, Chronic ObstructivePulmonary EmphysemaHumansInflammationNitric OxideX-Ray MicrotomographyNitric OxideChronic obstructive pulmonary diseaseFeNO200Peripheral airwaysSmall airway inflammation

Identifiers

PMID38443860
PMCPMC10916214

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.