ArticleThe journal of physiological sciences : JPS2024
Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male mice.
Article in The journal of physiological sciences : JPS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 4 citations in OpenAlex.
- Effects of excessive iodine intake during the perinatal period on thyroid function and higher brain functions in mouse offspring.Endocrine journal · 2025Article
- Persistent pollutants and the developing brain: the role of PFAS in neurodevelopmental disorders.Frontiers in cellular neuroscience · 2025Review
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6 authors at 2 institutions in 1 country.
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Abstract
Perfluorooctane sulfonate (PFOS) exerts adverse effects on neuronal development in young population. Limited evidences have shown that early-life PFOS exposure holds a potential risk for developing age-related neurodegenerative diseases such as Alzheimer's disease later in life. The present study investigated the effects of lactational PFOS exposure on cognitive function using one-year-old mice. Dams were exposed to PFOS (1 mg/kg body weight) through lactation by gavage. Male offspring were used for the behavior test battery to assess cognitive function. Western blot analysis was conducted to measure the levels of proteins related to the pathogenesis of Alzheimer's disease. PFOS-exposed mice displayed a mild deficiency in social recognition. In the hippocampus, the expression of tau protein was significantly increased. These results underline a mild effect of developing PFOS exposure on cognitive function and neurodegeneration. The present study presents the long-lasting effects of PFOS in middle-aged period and warrants a potential aftermath.
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