ArticleBMC microbiology2024
RpoS role in antibiotic resistance, tolerance and persistence in E. coli natural isolates.
Article in BMC microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Fermented Navy Bean-Derived Agents Restore Antibiotic Susceptibility inJournal of microbiology and biotechnology · 2026Article
- Beyond the Standard Antibiogram: Unveiling the Roles of pH and Salinity in Modulating Gentamicin Efficacy Against Escherichia coli in Urinary Tract Infections.MicrobiologyOpen · 2026Article
- Double agent: how Escherichia coli switches from commensal to pathogen in the urinary tract infection.Infection · 2026Review
- The SOS Response: A Double-Edged Sword between the Persister and Resister Formation.ACS omega · 2026Review
- Environmental pollutants as modifiers of antimicrobial resistance risk across food systems: a One Health perspective.Frontiers in public health · 2026Review
- An uncharacterized small protein MicN mediates the transcriptional reprogramming of Salmonella through regulating the RpoS-RNA polymerase interaction.Communications biology · 2025Article
- Salmonella stress response systems as targets for anti-virulence strategies.BMC microbiology · 2025Article
- Observation of persister cell histories reveals diverse modes of survival in antibiotic persistence.eLife · 2025Article
- Prevalence and molecular characterization of multi-drug and extreme drug resistant Escherichia coli in companion animals in Bangladesh.Scientific reports · 2025Article
- Glucose alters the evolutionary response to gentamicin in uropathogenicMicrobiology (Reading, England) · 2025Article
- (p)ppGpp mediates persister formation inFrontiers in microbiology · 2025Article
- Bacterial persisters: molecular mechanisms and therapeutic development.Signal transduction and targeted therapy · 2024Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe intrinsic concentration of RpoS, the second most abundant sigma factor, varies widely across the E. coli species. Bacterial isolates that express high levels of RpoS display high resistance to environmental stresses, such as temperature, pH and osmolarity shifts, but are less nutritional competent, making them less capable of utilising alternative nutrient sources. The role of RpoS in antibiotic resistance and persistence in standard laboratory domesticated strains has been examined in several studies, most demonstrating a positive role for RpoS.
resultsUsing disk diffusion assays we examined bacterial resistance to 15 different antibiotics, including
conclusionBased on a representative collection of the species E. coli, RpoS was found to have a very small impact on antibiotic resistance, tolerance, or persistence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.