Evidence map›Paper›PMID 38443733›Full record

ReviewCellular and molecular neurobiology2024

Unraveling the Neural Circuits: Techniques, Opportunities and Challenges in Epilepsy Research.

Wenjie Xiao, Peile Li, Fujiao Kong, Jingyi Kong, Aihua Pan, Lili Long, Xiaoxin Yan, Bo Xiao, Jiaoe Gong, Lily Wan

Open access · hybridAbstract readReview
In one paragraph

Review in Cellular and molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Antiepileptic and antiepileptogenic effects ofIBRO neuroscience reports · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Wenjie XiaoDepartment of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan Province, China.
Peile LiDepartment of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan Province, China.
Fujiao KongDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Jingyi KongDepartment of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan Province, China.
Aihua PanDepartment of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan Province, China.
Lili LongDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xiaoxin YanDepartment of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan Province, China.
Bo XiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Jiaoe GongDepartment of Neurology, Hunan Children's Hospital, Changsha, Hunan Province, China. 506432871@qq.com.
Lily WanDepartment of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan Province, China. wanll1203@csu.edu.cn.
Central South University · CNXiangya Hospital Central South University · CNHunan Children's Hospital · CN

Funding

Hunan Provincial Science and Technology Foundation #2022JJ40817the Key research and development program of Hunan Province of China #2022SK2042the National Multidisciplinary Cooperative Diagnosis and Treatment Capacity Project for Major Diseases of Xiangya Hospital, Central South University z027001the Scientific Research Project of Hunan Provincial Health Commission #20200475
6 · The paper itself

Abstract

Epilepsy, a prevalent neurological disorder characterized by high morbidity, frequent recurrence, and potential drug resistance, profoundly affects millions of people globally. Understanding the microscopic mechanisms underlying seizures is crucial for effective epilepsy treatment, and a thorough understanding of the intricate neural circuits underlying epilepsy is vital for the development of targeted therapies and the enhancement of clinical outcomes. This review begins with an exploration of the historical evolution of techniques used in studying neural circuits related to epilepsy. It then provides an extensive overview of diverse techniques employed in this domain, discussing their fundamental principles, strengths, limitations, as well as their application. Additionally, the synthesis of multiple techniques to unveil the complexity of neural circuits is summarized. Finally, this review also presents targeted drug therapies associated with epileptic neural circuits. By providing a critical assessment of methodologies used in the study of epileptic neural circuits, this review seeks to enhance the understanding of these techniques, stimulate innovative approaches for unraveling epilepsy's complexities, and ultimately facilitate improved treatment and clinical translation for epilepsy.

Indexed as

EpilepsyHumansSeizuresDevelopment historyDrug therapyEpilepsyNeural circuitsTechniques

Identifiers

PMID38443733
PMCPMC10914928
OpenAlexW4392515243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.