Evidence map›Paper›PMID 38443677›Full record

ArticleMikrochimica acta2024

A novel electrochemical immunosensor for sensitive detection of depression marker Apo-A4 based on bipyridine-functionalized covalent organic frameworks.

Yan Chen, Min Guo, Zixia Wang, Xiaohui Mo, Fangdi Hu, Yongling Du

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yan ChenSchool of Pharmacy, State Key Laboratory of Applied Organic Chemistry, Codonopsis Radix Industrial Technology Engineering Research Center, Lanzhou University, Lanzhou, 730000, Gansu Province, China.
Min GuoSchool of Pharmacy, State Key Laboratory of Applied Organic Chemistry, Codonopsis Radix Industrial Technology Engineering Research Center, Lanzhou University, Lanzhou, 730000, Gansu Province, China.
Zixia WangSchool of Pharmacy, State Key Laboratory of Applied Organic Chemistry, Codonopsis Radix Industrial Technology Engineering Research Center, Lanzhou University, Lanzhou, 730000, Gansu Province, China.
Xiaohui MoSchool of Pharmacy, State Key Laboratory of Applied Organic Chemistry, Codonopsis Radix Industrial Technology Engineering Research Center, Lanzhou University, Lanzhou, 730000, Gansu Province, China.
Fangdi HuSchool of Pharmacy, State Key Laboratory of Applied Organic Chemistry, Codonopsis Radix Industrial Technology Engineering Research Center, Lanzhou University, Lanzhou, 730000, Gansu Province, China. hufd@lzu.edu.cn.
Yongling DuCollege of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China. duyl@lzu.edu.cn.
Lanzhou University · CN

Funding

National Natural Science Foundation of China 81972018the Central Government Guiding Local Science and Technology Development Fund Project 22ZY1QA012the Gansu Province People's Livelihood Science and Technology Special Project - Rural Revitalization Special Project 22CX2NK004the major science and technology project of Gansu Province 21ZD4FA013the Special Project of Science and Technology Commissioner of Gansu Province 22CX8GA009the Talent Innovation and Entrepreneurship Project of Lanzhou 2017-RC -115the Talent Innovation and Entrepreneurship Project of Lanzhou 2020-RC-41
6 · The paper itself

Abstract

A novel electrochemical immunosensor for detecting potential depression biomarker Apolipoprotein A4 (Apo-A4) was developed using a multi-signal amplification approach. Firstly, the sensor utilized a modified electrode material, NG-PEI-COF, combining bipyridine-functionalized covalent organic framework (COF) and polyethyleneimine-functionalized nitrogen-doped graphene (NG-PEI), providing high surface area and excellent electron transfer capability for the first-stage amplification in electrical signal conduction. Subsequently, gold nanoparticles (AuNPs) were further electrodeposited onto the electrode, providing good biocompatibility and abundant binding sites for immobilizing the target antigen, thus achieving the second-stage amplification in target recognition and binding. To address the lack of redox properties of the antigen, a tracer probe was formed by loading AuNPs, anti-Apo-A4, and toluidine blue (TB) successively onto COF, leading to the third-stage amplification in signal conversion. The constructed electrochemical immunosensor TB/Ab/AuNPs/COF-Apo-A4/AuNPs/NG-PEI-COF/GCE exhibited excellent detection performance against Apo-A4 with a linear range of 0.01 to 300 ng mL

Indexed as

Apolipoproteins ABiosensing TechniquesMetal NanoparticlesMetal-Organic FrameworksDepressionGoldImmunoassayReproducibility of ResultsTolonium Chlorideapolipoprotein A-IVApolipoproteins AGoldMetal-Organic FrameworksTolonium ChlorideApo-A4Covalent organic frameworksDepressionElectrochemical immunosensor; Modified electrode; Square wave voltammetryNitrogen-doped graphene

Identifiers

PMID38443677
OpenAlexW4392448537

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.