Evidence map›Paper›PMID 38443604›Full record

ArticleClinical rheumatology2024

Increased carotid intima-media thickness in patients with radiographic axial spondyloarthritis compared to controls and associations with markers of inflammation.

Lucy Law, Per Lindqvist, Per Liv, Urban Hellman, Kristina Lejon, Mats Geijer, Stefan Söderberg, Helena Forsblad-d'Elia

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical rheumatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lucy LawDepartment of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden. lucy.law@umu.se.ORCID http://orcid.org/0000-0002-8129-8771
Per LindqvistDepartment of Surgical and Perioperative Sciences, Clinical Physiology, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-8192-9166
Per LivDepartment of Public Health and Clinical Medicine, Section of Sustainable Health, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-5494-8134
Urban HellmanDepartment of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-3822-0725
Kristina LejonDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0001-5025-6539
Mats GeijerDepartment of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0003-0529-7723
Stefan SöderbergDepartment of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0001-9225-1306
Helena Forsblad-d'EliaDepartment of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0001-7871-5303
Umeå University · SELund University · SESahlgrenska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThere is an increased risk for cardiovascular disease (CVD) in patients with radiographic axial spondyloarthritis (r-axSpA). In this cross-sectional study, we aimed to, overall and stratified by sex, (i) compare ultrasound derived carotid intima media thickness (cIMT), between patients and controls, and (ii) investigate associations between cIMT, clinical disease activity and inflammation-related laboratory markers in patients with r-axSpA.

methodIn total, 155 patients diagnosed with r-axSpA using the modified New York criteria and 400 controls were included. Bilateral carotid ultrasound, laboratory testing, and questionaries were acquired. Disease-specific assessments were carried out for patients. Linear regression analysis was used to assess associations.

resultsLinear regression analyses showed that patients with r-axSpA had increased mean cIMT compared to controls (mean ± SD, 0.8 ± 0.1 mm vs 0.7± 0.1 mm, respectively, unstandardized β (95% CI) -0.076 (-0.10, -0.052), P < 0.001) adjusted for smoking status and age. Linear regression analyses for patients with r-axSpA showed that only males presented significant associations between cIMT and inflammation-related laboratory markers, white blood cell (WBC) count (mean ± SD, 6.8 ± 1.6 10

conclusionPatients with r-axSpA had significantly increased cIMT compared to controls. In male patients, higher WBC and monocyte count were associated with an increase in cIMT suggesting the role of inflammation in the development of atherosclerosis. Key Points •Carotid intima-media thickness was increased in patients with radiographic axial spondyloarthritis compared to controls. •White blood cell and monocyte counts were associated with carotid intima-media thickness in male patients with radiographic axial spondyloarthritis.

Indexed as

Axial SpondyloarthritisCarotid Intima-Media ThicknessBiomarkersCross-Sectional StudiesHumansInflammationMaleRisk FactorsBiomarkersCardiovascular disease (CVD)Carotid intima-media thickness (cIMT)Radiographic axial spondyloarthritis (r-axSpA)Ultrasound

Identifiers

PMID38443604
PMCPMC11018678
OpenAlexW4392570771

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.