Thyroid-stimulating hormone levels are associated with estradiol levels and impact reproductive outcomes in preconceptionally euthyroid women undergoing their first IVF/ICSI cycles.

Yuchao Zhang, Jiaheng Li, Yanli Liu, Zhen Li, Yichun Guan

Abstract read

In one paragraph

Article in Hormones (Athens, Greece), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

0.7field-weighted citation impact, top 29% of its field

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Authors and funding

5 authors at 1 institution in 1 country.

Yuchao Zhang *Department of Reproductive Medicine, The Third Affiliated Hospital of Zhengzhou University, No.7 Kangfuqian Street, Erqi, Zhengzhou, Henan, 450052, China. yuchao1988@yeah.net.

Jiaheng Li *Department of Reproductive Medicine, The Third Affiliated Hospital of Zhengzhou University, No.7 Kangfuqian Street, Erqi, Zhengzhou, Henan, 450052, China.

Yanli LiuDepartment of Reproductive Medicine, The Third Affiliated Hospital of Zhengzhou University, No.7 Kangfuqian Street, Erqi, Zhengzhou, Henan, 450052, China.

Zhen LiDepartment of Reproductive Medicine, The Third Affiliated Hospital of Zhengzhou University, No.7 Kangfuqian Street, Erqi, Zhengzhou, Henan, 450052, China.

Yichun GuanDepartment of Reproductive Medicine, The Third Affiliated Hospital of Zhengzhou University, No.7 Kangfuqian Street, Erqi, Zhengzhou, Henan, 450052, China. lisamayguan@163.com.

Third Affiliated Hospital of Zhengzhou University · CN

Funding

Joint Construction Project of Henan Medical Science and Technology Research Plan LHGJ20190365Joint Construction Project of Henan Medical Science and Technology Research Plan LHGJ20190400National Key R&D Program 2021YFC2700602

6 · The paper itself

Abstract

purposeControlled ovarian hyperstimulation (COH) has been reported to affect thyroid function; however, the impact of thyroid-stimulating hormone (TSH) levels during COH on embryo development and early reproductive outcomes has largely not been determined. Therefore, the aim of the present study was to investigate whether TSH levels are associated with COH and impact early reproductive outcomes in preconceptionally euthyroid women.

methodsThis was a prospective cohort study. A total of 338 euthyroid women who underwent their first in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment using the gonadotropin releasing hormone agonist (GnRH-a) protocol were included. Samples were collected at different representative time points for TSH and estradiol measurements.

resultsTSH levels significantly increased with the administration of Gn and maintained this tendency until the trigger day. Basal TSH levels increased along with basal estradiol levels and remained stable when estradiol levels were higher than 150 pmol/L. On the trigger day, TSH levels changed with increasing estradiol levels in the high-normal basal TSH group but not in the low TSH group. TSH did not impact clinical pregnancy or early pregnancy loss after adjusting for age, stage or number of embryos. CONCLUSION(S): Serum TSH levels change significantly during COH and are associated with significant changes in estradiol levels. However, euthyroid women with high-normal TSH levels showed similar development potential for inseminated embryos and early reproductive outcomes compared to those with low TSH levels.

Indexed as

EstradiolFertilization in VitroOvulation InductionSperm Injections, IntracytoplasmicThyrotropinAdultFemaleHumansPregnancyPregnancy OutcomePregnancy RateProspective StudiesEstradiolThyrotropinClinical pregnancyCOHEstradiolGnRH-aMiscarriageTSH

Identifiers

PMID38443586

DOI10.1001/jama.2017.18249

OpenAlexW4392515952

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.