ArticleNPJ genomic medicine2024
Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease.
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Article in NPJ genomic medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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0cells of the map it votes in
1citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
What it found
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Who cites it
1 citing paper in PubMed, 5 citations in OpenAlex.
- Hologenomic analysis of rectal mucus sampling for detection of adenomatous polyps and colorectal cancer.Nature communications · 2025Article
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Authors and funding
63 authors at 20 institutions in 9 countries.
Dhanya RamachandranGynaecology Research Unit, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0001-8139-7799
Jonathan P TyrerCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Stefan KommossDepartment of Women's Health, Tuebingen University Hospital, Tuebingen, Germany.
Anna DeFazioCentre for Cancer Research, The Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, Australia.
Marjorie J RigganDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0002-3701-8031
AOCS Group
Penelope M WebbPopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-0733-5930
Peter A FaschingDepartment of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.
Diether LambrechtsLaboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.
María J GarcíaBiochemistry and Molecular Biology area, Department of Basic Health Sciences, Faculty of Health Sciences, Rey Juan Carlos University, Madrid, Spain.
Cristina Rodríguez-AntonaHereditary Endocrine Cancer Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain.ORCID http://orcid.org/0000-0001-8750-7338
Marc T GoodmanCancer Prevention and Control Program, Cedars-Sinai Cancer, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Francesmary ModugnoDepartment of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA.
Kirsten B MoysichDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
Beth Y KarlanDavid Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-9451-2933
Jenny LesterDavid Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA.
Susanne K KjaerDepartment of Virus, Lifestyle and Genes, Danish Cancer Institute, Copenhagen, Denmark.
Allan JensenDepartment of Virus, Lifestyle and Genes, Danish Cancer Institute, Copenhagen, Denmark.
Estrid HøgdallDepartment of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Ellen L GoodeDepartment of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
William A ClibyDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mayo Clinic, Rochester, MN, USA.
Amanika KumarDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mayo Clinic, Rochester, MN, USA.
Chen WangDepartment of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, MN, USA.
Julie M CunninghamDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Stacey J WinhamDepartment of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, MN, USA.
Alvaro N MonteiroDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-8448-4801
Joellen M SchildkrautDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Daniel W CramerObstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gyneclogy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Kathryn L TerryObstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gyneclogy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Linda TitusNorris Cotton Cancer Center, Lebanon, NH, USA.
Line BjorgeDepartment of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
Liv Cecilie Vestrheim ThomsenDepartment of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
OPAL Study Group
Tanja PejovicDepartment of ObGyn, Providence Medical Center, Medford, OR, USA.
Claus K HøgdallDepartment of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Iain A McNeishDivision of Cancer and Ovarian Cancer Action Research Centre, Department Surgery & Cancer, Imperial College London, London, UK.
Taymaa MayDivision of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, Toronto, ON, Canada.
David G HuntsmanDepartment of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada.
Jacobus PfistererGynecologic Oncology Center, Kiel, Germany.
Ulrich CanzlerUniversity Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Tjoung-Won Park-SimonGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Willibald SchröderKlinikum Bremen-Mitte, Bremen, Germany.
Antje BelauUniversity Hospital Greifswald, Greifswald, Germany.
Lars HankerUniversity Hospital Frankfurt, Frankfurt, Germany.
Philipp HarterDepartment of Gynecology and Gynecologic Oncology, Evangelische Kliniken Essen-Mitte (KEM), Essen, Germany.
Jalid SehouliCharité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany.
Rainer KimmigUniversity Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Nikolaus de GregorioUniversity Hospital Ulm, Ulm, Germany.
Barbara SchmalfeldtUniversity Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Klaus BaumannUniversity Hospital Gießen and Marburg, Site Marburg, Marburg, Germany.
Felix HilpertUniversity Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Alexander BurgesUniversity Hospital LMU Munich, Munich, Germany.
Boris WinterhoffDepartment of Obstetrics, Gynecology and Women's Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, MN, USA.
Peter SchürmannGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Lisa-Marie SpeithGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Peter HillemannsGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Andrew BerchuckDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University Medical Center, Durham, NC, USA.
Sharon E JohnattyCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Susan J RamusSchool of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, NSW, Australia.
Georgia Chenevix-TrenchCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Paul D P PharoahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-8494-732X
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover, Germany. doerk.thilo@mh-hannover.de.ORCID http://orcid.org/0000-0002-9458-0282
Florian HeitzDepartment of Gynecology and Gynecologic Oncology, Evangelische Kliniken Essen-Mitte (KEM), Essen, Germany. F.Heitz@kem-med.com.ORCID http://orcid.org/0000-0002-2412-0352
QIMR Berghofer Medical Research Institute · AUUniversity of Copenhagen · DKMayo Clinic in Arizona · USMedizinische Hochschule Hannover · DECedars-Sinai Medical Center · USPeter MacCallum Cancer Centre · AUBrigham and Women's Hospital · USGoethe University Frankfurt · DEHaukeland University Hospital · NOOregon Health & Science University · USRoswell Park Comprehensive Cancer Center · USUniversidad Rey Juan Carlos · ESUniversität Hamburg · DEUniversitätsklinikum Gießen und Marburg · DEUniversitätsmedizin Greifswald · DEUniversity of British Columbia · CAUniversity of Minnesota · USCancer Institute of New South Wales · AUCotton (United States) · USDuke Medical Center · US
Funding
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0MWomen's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MUse of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI SCOTT H KAUFMANN · 2009 to 2026
$37.0MWITHIN SUBJ VARIABILITY IN MEASUREMENTS DRUG METABOL ENZYMES IN HLTY SUBJM01RR000056 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEVINE, ARTHUR S · 1985 to 2006
$29.2MNovel Serum, Plasma, and Urine Biomarkers of Ovarian CanP50CA105009 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI CRAMER, DANIEL WILLIAM · 2004 to 2010
$13.3MOvarian cancer GWAS discovery, expansion and replication (N2 - Project #1)U19CA148112 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SELLERS, THOMAS A · 2010 to 2014
$10.2MThe Molecular Epidemiology Of Ovarian CancerR01CA076016 · NCI · DUKE UNIVERSITY · PI SCHILDKRAUT, JOELLEN M. · 1998 to 2010
$6.2MOVARIAN CANCER RISK AND HYPERGONADOTROPIC HYPOGONADISMR01CA054419 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI CRAMER, DANIEL WILLIAM · 1992 to 2007
$5.9MRelating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and RiskR01CA248288 · NCI · MAYO CLINIC ROCHESTER · PI Stacey J Winham · 2021 to 2026
$4.8MNCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NCI NIH HHS K05 CA154337NCI NIH HHS K07 CA080668NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA047904NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA105009NCI NIH HHS P50 CA136393NCI NIH HHS R01 CA054419NCI NIH HHS R01 CA058598NCI NIH HHS R01 CA076016NCI NIH HHS R01 CA095023NCI NIH HHS R01 CA149429NCI NIH HHS R01 CA248288NCI NIH HHS R21 CA267050NCI NIH HHS U19 CA148112NCRR NIH HHS M01 RR000056Wellcome Trust
Abstract
Survival from ovarian cancer depends on the resection status after primary surgery. We performed genome-wide association analyses for resection status of 7705 ovarian cancer patients, including 4954 with high-grade serous carcinoma (HGSOC), to identify variants associated with residual disease. The most significant association with resection status was observed for rs72845444, upstream of MGMT, in HGSOC (p = 3.9 × 10
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