Evidence map›Paper›PMID 38443074›Full record

Trial reportBMJ (Clinical research ed.)2024

Diagnostic accuracy of magnetically guided capsule endoscopy with a detachable string for detecting oesophagogastric varices in adults with cirrhosis: prospective multicentre study.

Xi Jiang, Jun Pan, Qing Xu, Yu-Hu Song, Huan-Huan Sun, Cheng Peng, Xiao-Long Qi, Yang-Yang Qian, Wen-Bin Zou, Yang Yang and 47 more

Registry-linked trialOpen access · hybridAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03748563 (Accuracy of Magnetically Maneuvered Capsule Endoscopy for Detection of Esophagogastric Varices in Patients With Cirrhosis), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03748563 nacompletednot on this map

Accuracy of Magnetically Maneuvered Capsule Endoscopy for Detection of Esophagogastric Varices in Patients With Cirrhosis

TypeinterventionalSponsorChanghai HospitalRan2021 to 2023Enrolled607ConditionsLiver Cirrhosis, Portal Hypertension, Esophageal Varices, Gastric VarixArmsds-MCE and EGD
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Review
  3. Prevention of Gastric Cancer.Medicina (Kaunas, Lithuania) · 2026
    Review
  4. [Novel advances following the integration of Baveno VII consensus definitions for the non-invasive testing of portal hypertension].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

57 authors at 17 institutions in 2 countries.

Xi JiangDepartment of Gastroenterology, Changhai Clinical Research Unit, National Clinical Research Centre for Digestive Diseases, National Key Laboratory of Immunity and Inflammation, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Jun PanDepartment of Gastroenterology, Changhai Clinical Research Unit, National Clinical Research Centre for Digestive Diseases, National Key Laboratory of Immunity and Inflammation, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Qing XuDepartment of Gastroenterology and Hepatology, Tongji Hospital of Tongji University School of Medicine, Shanghai, China.
Yu-Hu SongDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Huan-Huan SunDepartment of Gastroenterology, Shanxi Clinical Research Centre of Digestive Disease (cancer division), the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Cheng PengDepartment of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xiao-Long QiCHESS Centre, Department of Radiology, Basic Medicine Research and Innovation Centre of Ministry of Education, Zhongda Hospital, Medical School, Southeast University, Nurturing Centre of Jiangsu Province for State Laboratory of AI Imaging and Interventional Radiology, Nanjing, China.
Yang-Yang QianDepartment of Gastroenterology, Changhai Clinical Research Unit, National Clinical Research Centre for Digestive Diseases, National Key Laboratory of Immunity and Inflammation, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Wen-Bin ZouDepartment of Gastroenterology, Changhai Clinical Research Unit, National Clinical Research Centre for Digestive Diseases, National Key Laboratory of Immunity and Inflammation, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Yang YangDepartment of Gastroenterology and Endoscopy, The Fifth affiliated Zhuhai Hospital of Zunyi Medical University, Zhuhai, China.
Shao-Qin JinDepartment of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Ben-Song DuanDepartment of Gastroenterology, Endoscopy Centre, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Shan WuDepartment of Endoscopy, The Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Ye ChuDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ding-Hua XiaoDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
Li-Juan HuDepartment of Gastroenterology, Shanghai Pudong New Area Gongli Hospital, Shanghai, China.
Jun-Zhi CaoDepartment of Gastroenterology, Yangpu Hospital, Tongji University, Shanghai, China.
Jin-Feng DaiDepartment of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Xiao LiuDepartment of Gastroenterology, Changhai Clinical Research Unit, National Clinical Research Centre for Digestive Diseases, National Key Laboratory of Immunity and Inflammation, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Tian XiaDepartment of Gastroenterology, Changhai Clinical Research Unit, National Clinical Research Centre for Digestive Diseases, National Key Laboratory of Immunity and Inflammation, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Wei ZhouDepartment of Gastroenterology, Changhai Clinical Research Unit, National Clinical Research Centre for Digestive Diseases, National Key Laboratory of Immunity and Inflammation, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Tao ChenDepartment of Gastroenterology, Endoscopy Centre, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Chun-Hua ZhouDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wei WuDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shao-Jun LiuDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
Zhen-Yu YangDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
Fen WangDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
Lu ZhangDepartment of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Cheng-Zhong LiDepartment of Infectious Diseases, Changhai Hospital, Naval Medical University, Shanghai, China.
Hao XuDepartment of Infectious Diseases, Changhai Hospital, Naval Medical University, Shanghai, China.
Jun-Xue WangDepartment of Infection, Changzheng Hospital, Naval Medical University, Shanghai, China.
Bo WeiDepartment of Infection, Changzheng Hospital, Naval Medical University, Shanghai, China.
Yong LinDepartment of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Xing DengDepartment of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Li-Hong QuDepartment of Infectious Diseases, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Ying-Qiu ShenDepartment of Infectious Diseases, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Hui WangDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yi-Fei HuangDepartment of Gastroenterology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Hai-Biao BaoDepartment of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Shuo ZhangDepartment of Gastroenterology, The Second Affiliated Hospital of Zhejiang Chinese University, Hangzhou, China.
Li LiDepartment of Gastroenterology, Yangpu Hospital, Tongji University, Shanghai, China.
Yi-Hai ShiDepartment of Gastroenterology, Shanghai Pudong New Area Gongli Hospital, Shanghai, China.
Xiao-Yan WangDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
Duo-Wu ZouDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xin-Jian WanDepartment of Endoscopy, The Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Mei-Dong XuDepartment of Gastroenterology, Endoscopy Centre, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Hua MaoDepartment of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Chao-Hui HeDepartment of Gastroenterology and Endoscopy, The Fifth affiliated Zhuhai Hospital of Zunyi Medical University, Zhuhai, China.
Zhen LiDepartment of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xiu-Li ZuoDepartment of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Shui-Xiang HeDepartment of Gastroenterology, Shanxi Clinical Research Centre of Digestive Disease (cancer division), the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xiao-Ping XieDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jun LiuDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chang-Qing YangDepartment of Gastroenterology and Hepatology, Tongji Hospital of Tongji University School of Medicine, Shanghai, China.
Cristiano SpadaDigestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Zhao-Shen LiDepartment of Gastroenterology, Changhai Clinical Research Unit, National Clinical Research Centre for Digestive Diseases, National Key Laboratory of Immunity and Inflammation, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Zhuan LiaoDepartment of Gastroenterology, Changhai Clinical Research Unit, National Clinical Research Centre for Digestive Diseases, National Key Laboratory of Immunity and Inflammation, Changhai Hospital, Naval Medical University, Shanghai 200433, China liaozhuan@smmu.edu.cn.ORCID 0000-0001-8506-8159
Second Military Medical University · CNShanghai Jiao Tong University · CNCentral South University · CNShanghai East Hospital · CNShanghai Changzheng Hospital · CNUnion Hospital · CNZhejiang Chinese Medical University · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNQilu Hospital of Shandong University · CNTongji University · CNYangpu Hospital of Tongji University · CNZhujiang Hospital · CNZunyi Medical University · CNAgostino Gemelli University Polyclinic · ITSecond Affiliated Hospital of Zhejiang University · CNSoutheast University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the diagnostic accuracy and safety of using magnetically guided capsule endoscopy with a detachable string (ds-MCE) for detecting and grading oesophagogastric varices in adults with cirrhosis.

designProspective multicentre diagnostic accuracy study.

setting14 medical centres in China.

participants607 adults (>18 years) with cirrhosis recruited between 7 January 2021 and 25 August 2022. Participants underwent ds-MCE (index test), followed by oesophagogastroduodenoscopy (OGD, reference test) within 48 hours. The participants were divided into development and validation cohorts in a ratio of 2:1.

main outcome measuresThe primary outcomes were the sensitivity and specificity of ds-MCE in detecting oesophagogastric varices compared with OGD. Secondary outcomes included the sensitivity and specificity of ds-MCE for detecting high risk oesophageal varices and the diagnostic accuracy of ds-MCE for detecting high risk oesophagogastric varices, oesophageal varices, and gastric varices.

resultsds-MCE and OGD examinations were completed in 582 (95.9%) of the 607 participants. Using OGD as the reference standard, ds-MCE had a sensitivity of 97.5% (95% confidence interval 95.5% to 98.7%) and specificity of 97.8% (94.4% to 99.1%) for detecting oesophagogastric varices (both P<0.001 compared with a prespecified 85% threshold). When using the optimal 18% threshold for luminal circumference of the oesophagus derived from the development cohort (n=393), the sensitivity and specificity of ds-MCE for detecting high risk oesophageal varices in the validation cohort (n=189) were 95.8% (89.7% to 98.4%) and 94.7% (88.2% to 97.7%), respectively. The diagnostic accuracy of ds-MCE for detecting high risk oesophagogastric varices, oesophageal varices, and gastric varices was 96.3% (92.6% to 98.2%), 96.9% (95.2% to 98.0%), and 96.7% (95.0% to 97.9%), respectively. Two serious adverse events occurred with OGD but none with ds-MCE.

conclusionThe findings of this study suggest that ds-MCE is a highly accurate and safe diagnostic tool for detecting and grading oesophagogastric varices and is a promising alternative to OGD for screening and surveillance of oesophagogastric varices in patients with cirrhosis.

trial registrationClinicalTrials.gov NCT03748563.

Indexed as

Capsule EndoscopyEsophageal and Gastric VaricesVaricose VeinsAdultHumansLiver CirrhosisProspective Studies

Identifiers

PMID38443074
PMCPMC10912951
OpenAlexW4392456032

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.