ReviewAutophagy2024
International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis.
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In one paragraph
Review in Autophagy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers.
0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
142 citing papers in PubMed.
- Ginkgolic acid targets HSPA8 to trigger ferroptosis in hepatocellular carcinomaPharmaceutical biology · 2026Article
- Cell death in ischemia-reperfusion injury: beyond a single-cell-death perspective.Biomarker research · 2026Review
- Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis.Andrology · 2026Article
- Ferroptosis in liver biology and diseases.Hepatology communications · 2026Review
- Drugging small-molecule compounds in autophagy-dependent cell death to overcome cancer therapy resistance.Apoptosis : an international journal on programmed cell death · 2026Review
- Ferroptosis regulatory networks as therapeutic sensitizers in combination therapy for hepatocellular carcinoma (Review).Oncology letters · 2026Review
- Nanomaterial-driven spatiotemporal autophagy modulation: The dual-edged sword in precision cancer therapy.Acta pharmaceutica Sinica. B · 2026Review
- Autophagy modulation in cancer.Nature reviews. Drug discovery · 2026Review
- Autophagy Orchestrates Anti-Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP-2 Axis in Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Identification of a New, Potent, and Stable Tetrahydroquinoline-Based 5-LOX/sEH Dual Inhibitor with Polymodal Anti-Inflammatory Activity in Acute Pancreatitis.Journal of medicinal chemistry · 2026Article
- Ferroptosis and aging: Inducing and catalyzing neurodegenerative diseases.Neural regeneration research · 2026Article
- The nuclear receptor ESRRA is a crucial regulator of acute kidney injury through inhibition of the lipophagy-ferroptosis axis.Autophagy · 2026Article
- Ferroptosis in depression: mechanisms, association, and therapeutic strategies.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- OTUB1 inhibits autophagy-dependent ferroptosis in hepatocellular carcinoma by stabilizing p62 via non-canonical deubiquitination.Cell death discovery · 2026Article
- Organelle regulation of ferroptosis after intracerebral hemorrhage.Redox biology · 2026Review
- CORO1A, A Novel Upregulated Protein in Renal Tubular Epithelial Cells of Diabetic Nephropathy, Participates in Regulating Vesicular Trafficking and the Ferroptosis Pathway.Nephrology (Carlton, Vic.) · 2026Article
- Crosstalk of thioredoxin system and programmed cell death: from pathophysiology to novel therapy.Redox biology · 2026Review
- Review
- Targeting Ferroptosis in Glioblastoma: Molecular Mechanisms, Tumor Microenvironment, and Therapeutic Opportunities.Cancers · 2026Review
- α-tubulin N-acetyltransferase 1 regulates NCOA4-mediated ferritinophagy and protects cancer cells from ferroptosis.Cellular & molecular biology letters · 2026Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
69 authors.
Xin ChenGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.ORCID 0000-0003-3668-4830
Andrey S TsvetkovDepartment of Neurology, The University of Texas McGovern Medical School at Houston, Houston, TX, USA.
Han-Ming ShenDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Macau, China.
Ciro IsidoroDepartment of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Nicholas T KtistakisBabraham Institute, Cambridge, UK.
Andreas LinkermannDivision of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany.
Werner J H KoopmanDepartment of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Hans-Uwe SimonInstitute of Pharmacology, University of Bern, Bern, Switzerland.ORCID 0000-0002-9404-7736
Lorenzo GalluzziDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Shouqing LuoPeninsula Medical School, University of Plymouth, Plymouth, UK.
Daqian XuZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
Wei GuInstitute for Cancer Genetics, and Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Olivier PeulenMetastasis Research Laboratory, GIGA Cancer-University of Liège, Liège, Belgium.
Qian CaiDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
David C RubinszteinDepartment of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.ORCID 0000-0001-5002-5263
Jen-Tsan ChiDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
Donna D ZhangPharmacology and Toxicology, R. Ken Coit College of Pharmacy, University of Arizona, Tucson, AZ, USA.
Changfeng LiDepartment of Endoscopy Center, China-Japan Union Hospital of Jilin University, Changchun, China.
Shinya ToyokuniDepartment of Pathology and Biological Response, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Jinbao LiuAffiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Jong-Lyel RohDepartment of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
Enyong DaiThe Second Department of Hematology and Oncology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
Gabor JuhaszBiological Research Center, Institute of Genetics, Szeged, Hungary.
Wei LiuDepartment of Orthopedics, Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Jianhua ZhangDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Minghua YangDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jiao LiuDAMP Laboratory, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Ling-Qiang ZhuDepartment of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Weiping ZouDepartments of Surgery and Pathology, University of Michigan Medical School, Ann Arbor, USA.
Mauro PiacentiniDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.
Wen-Xing DingDepartment of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS, USA.
Zhenyu YueDepartment of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yangchun XieDepartment of Oncology, Central South University, Changsha, Hunan, China.
Morten PetersenFunctional genomics, Department of Biology, Copenhagen University, Denmark.
David A GewirtzDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA, USA.ORCID 0000-0003-0437-4934
Michael A MandellDepartment of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, USA.
Charleen T ChuPathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Debasish SinhaDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA; Wilmer Eye lnstitute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Eftekhar EftekharpourDepartment of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.
Boris ZhivotovskyInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Europe.
Sébastien BesteiroLPHI, University Montpellier, CNRS, Montpellier, France.
Dmitry I GabrilovichAstraZeneca, Early Oncology R&D, Gaithersburg, MD, USA.
Do-Hyung KimDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Valerian E KaganDepartment of Environmental Health, University of Pittsburgh, Pittsburgh, PA, USA.
Hülya BayirDepartment of Pediatrics, Columbia University, New York, USA.
Guang-Chao ChenInstitute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Scott AytonFlorey Institute, University of Melbourne, Parkville, Australia.
Jan D LünemannDepartment of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.
Masaaki KomatsuDepartment of Physiology, Juntendo University School of Medicine, Bunkyo-ku Tokyo, Japan.
Stefan KrautwaldDepartment of Nephrology and Hypertension, University Hospital Schleswig-Holstein, Kiel, Germany.
Ben LoosDepartment of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.
Eric H BaehreckeDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Jiayi WangDepartment of Clinical Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jon D LaneSchool of Biochemistry, University of Bristol, Bristol, UK.
Junichi SadoshimaRutgers New Jersey Medical School, Department of Cell Biology and Molecular Medicine, Newark, USA.
Wan Seok YangDepartment of Biological Sciences, St. John's University, New York City, NY, USA.
Minghui GaoThe HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Christian MünzInstitute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Michael ThummDepartment of Cellular Biochemistry, University Medical Center Goettingen, Goettingen, Germany.
Martin KampmannDepartment of Biochemistry & Biophysics, University of California, San Francisco, USA.
Di YuFaculty of Medicine, Frazer Institute, University of Queensland, Brisbane, Australia.
Marta M LipinskiDepartment of Anesthesiology & Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7537-9014
Jace W JonesDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA.
Xuejun JiangCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Herbert J ZehDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Rui KangDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Daniel J KlionskyLife Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-7828-8118
Guido KroemerCentre de Recherche des Cordeliers, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris, France.ORCID 0000-0002-9334-4405
Daolin TangDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MThe mechanism and regulation of autophagyR35GM131919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DANIEL J. KLIONSKY · 2019 to 2026
$6.4MThe Role of Abnormal Inter-Organelle Communication in the Pathogenesis of TauopathyR01NS089737 · NINDS · RUTGERS, THE STATE UNIV OF N.J. · PI Qian Cai · 2014 to 2026
$5.5MRegulation of autophagy during animal developmentR35GM131689 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Eric H Baehrecke · 2019 to 2026
$4.9MFerroptosis, Cellular Metabolism, and CancerR01CA204232 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JIANG, XUEJUN · 2017 to 2025
$4.1MMechanisms and Function of Autophagy in CancerR01CA166413 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JIANG, XUEJUN · 2013 to 2023
$3.9MTargeting HMGB1-mediated Autophagy in Cancer TherapyR01CA160417 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI TANG, DAOLIN · 2012 to 2023
$3.0MFerroptosis and Cancer Cell SignalingR01CA258622 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Xuejun Jiang · 2022 to 2026
$2.2MTargeting ACOD1 to attenuate innate immune responses to lethal infectionsR01GM127791 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Daolin Tang · 2018 to 2026
$2.2MCellular responses to retroviral capsid recognitionR01AI155746 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI MANDELL, MICHAEL AARON · 2021 to 2025
$2.1MMechanisms of Ferroptotic Cancer Cell DeathR01CA229275 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI TANG, DAOLIN · 2019 to 2024
$1.8MThe Pancreatic Cancer MicroenvironmentR01CA211070 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI KANG, RUI · 2017 to 2023
$1.4MBiotechnology and Biological Sciences Research Council BBS/E/B/000C0417NCI NIH HHS R01 CA160417NCI NIH HHS R01 CA211070NCI NIH HHS R01 CA229275NIA NIH HHS R21 AG089974NIGMS NIH HHS R35 GM131919NINDS NIH HHS R01 NS089737
Abstract
Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles. Conversely, other forms of selective autophagy (e.g. reticulophagy and lysophagy) enhance the cellular defense against ferroptotic damage. Dysregulated autophagy-dependent ferroptosis has implications for a diverse range of pathological conditions. This review aims to present an updated definition of autophagy-dependent ferroptosis, discuss influential substrates and receptors, outline experimental methods, and propose guidelines for interpreting the results.
Indexed as
AutophagyFerroptosisAnimalsConsensusHumansCell deathferritinophagyironlipid peroxidationlipophagylysosome
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