Evidence map›Paper›PMID 38442854›Full record

ArticleBiomedical journal2024

Altered purinergic P2X7 and A

Maria Luiza Thorstenberg, Monique Daiane Andrade Martins, Nathália Ferreira Oliveira, Matheus Macedo L V Monteiro, Gustavo R C Santos, Henrique M Gualberto Pereira, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva, Claudia Lucia Martins Silva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Maria Luiza ThorstenbergLaboratory of Biochemical and Molecular Pharmacology, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil.
Monique Daiane Andrade MartinsLaboratory of Immunophysiology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil.
Nathália Ferreira OliveiraLaboratory of Biochemical and Molecular Pharmacology, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil.
Matheus Macedo L V MonteiroLaboratory of Biochemical and Molecular Pharmacology, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil.
Gustavo R C SantosBrazilian Doping Control Laboratory (LBCD - LADETEC / IQ), Universidade Federal do Rio de Janeiro, Brazil.
Henrique M Gualberto PereiraBrazilian Doping Control Laboratory (LBCD - LADETEC / IQ), Universidade Federal do Rio de Janeiro, Brazil.
Luiz Eduardo Baggio SavioLaboratory of Immunophysiology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil.
Robson Coutinho-SilvaLaboratory of Immunophysiology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil.
Claudia Lucia Martins SilvaLaboratory of Biochemical and Molecular Pharmacology, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil. Electronic address: cmartins@icb.ufrj.br.
Universidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe occurrence of co-infections during schistosomiasis, a neglected tropical disease, with other parasites have been reported suggesting an impaired host immune defense. Macrophage purinergic P2X7 receptor (P2X7R) plays an important role against intracellular pathogens. Therefore, we investigated the P2X7R-mediated phagocytosis and killing capacity of Leishmania amazonensis by macrophages during schistosomiasis in vitro and in vivo.

methodsSwiss and C57BL/6 (Wild type) and P2X7R

resultsThe pre-treatment of control macrophages with the P2X7R antagonist (A74003) or TGF-β reduced the phagocytosis index, mimicking the phenotype of cells from S. mansoni-infected mice and P2X7R

conclusionsAltogether, the altered P2X7R and A

Indexed as

MacrophagesMice, Inbred C57BLPhagocytosisReceptors, Purinergic P2X7Signal TransductionAdenosine TriphosphateAnimalsLeishmaniaMiceSchistosoma mansoniSchistosomiasisAdenosine TriphosphateReceptors, Purinergic P2X7Adenosine receptorHost defenseLeishmaniasisMacrophagesP2X7 receptorSchistosomiasis

Identifiers

PMID38442854
PMCPMC11550761
OpenAlexW4392343895

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.