Evidence map›Paper›PMID 38442778›Full record

ArticleNeuroImage2024

Altered structural and functional connectivity in Posterior Cortical Atrophy and Dementia with Lewy bodies.

Neha Atulkumar Singh, Austin W Goodrich, Jonathan Graff-Radford, Mary M Machulda, Irene Sintini, Arenn F Carlos, Carling G Robinson, Robert I Reid, Val J Lowe, Clifford R Jack and 5 more

Open access · goldAbstract read
In one paragraph

Article in NeuroImage, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  6. A spatial covarianceJournal of neurology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Neha Atulkumar SinghDepartment of Neurology, Mayo Clinic, Rochester, MN, United States.
Austin W GoodrichDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States.
Jonathan Graff-RadfordDepartment of Neurology, Mayo Clinic, Rochester, MN, United States.
Mary M MachuldaDepartment of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, United States.
Irene SintiniDepartment of Radiology, Mayo Clinic, Rochester, MN, United States.
Arenn F CarlosDepartment of Neurology, Mayo Clinic, Rochester, MN, United States.
Carling G RobinsonDepartment of Neurology, Mayo Clinic, Rochester, MN, United States.
Robert I ReidDepartment of Radiology, Mayo Clinic, Rochester, MN, United States; Department of Information Technology, Mayo Clinic, Rochester, MN, United States.
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, MN, United States.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN, United States.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN, United States.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN, United States.
Keith A JosephsDepartment of Neurology, Mayo Clinic, Rochester, MN, United States.
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, MN, United States.
Jennifer L WhitwellDepartment of Radiology, Mayo Clinic, Rochester, MN, United States. Electronic address: whitwell.jennifer@mayo.edu.
Mayo Clinic in Arizona · USMayo Clinic · USMayo Clinic in Florida · US

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$33.5M
Longitudinal Imaging Biomarkers of Prodromal DLBU01NS100620 · NINDS · MAYO CLINIC ROCHESTER · PI Bradley F Boeve, KEJAL KANTARCI · 2017 to 2026
$19.2M
PREDICTING ALZHEIMERS DISEASE WITH MAGNETIC RESONANCER01AG011378 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R. · 1993 to 2017
$12.1M
Genetic Consortium for Late Onset Alzheimer's DiseaseU24AG026395 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2005 to 2009
$10.1M
Molecular and structural imaging in atypical Alzheimer's disease: a longitudinal studyR01AG050603 · NIA · MAYO CLINIC ROCHESTER · PI WHITWELL, JENNIFER LOUISE · 2016 to 2025
$5.9M
NEUROPSYCHOLOGY OF DEMENTIA WITH LEWY BODIESR01AG015866 · NIA · MAYO CLINIC JACKSONVILLE · PI FERMAN, TANIS JILL · 1999 to 2009
$2.6M
1H MRS markers of MCI syndromes and common dementiasK23AG030935 · NIA · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2007 to 2009
$630k
NIA NIH HHS K23 AG030935NIA NIH HHS P30 AG062677NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG011378NIA NIH HHS R01 AG015866NIA NIH HHS R01 AG050603NIA NIH HHS U01 AG006786NIA NIH HHS U24 AG026395NINDS NIH HHS U01 NS100620
6 · The paper itself

Abstract

Posterior cortical atrophy (PCA) and dementia with Lewy bodies (DLB) show distinct atrophy and overlapping hypometabolism profiles, but it is unknown how disruptions in structural and functional connectivity compare between these disorders and whether breakdowns in connectivity relate to either atrophy or hypometabolism. Thirty amyloid-positive PCA patients, 24 amyloid-negative DLB patients and 30 amyloid-negative cognitively unimpaired (CU) healthy individuals were recruited at Mayo Clinic, Rochester, MN, and underwent a 3T head MRI, including structural MRI, resting state functional MRI (rsfMRI) and diffusion tensor imaging (DTI) sequences, as well as [

Indexed as

Alzheimer DiseaseLewy Body DiseaseAtrophyDiffusion Tensor ImagingFluorodeoxyglucose F18HumansMagnetic Resonance ImagingFluorodeoxyglucose F18Dementia with Lewy bodiesDiffusion tensor imagingMultimodal imaging analysisPosterior cortical atrophyResting state functional connectivity

Identifiers

PMID38442778
PMCPMC11019668
OpenAlexW4392343919

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.