Evidence map›Paper›PMID 38442133›Full record

ArticlePloS one2024

ABCG2 transporter reduces protein aggregation in cigarette smoke condensate-exposed A549 lung cancer cells.

Emmanuella O Ajenu, Ashley M Seideneck, Esh Pandellapalli, Emily M Shinsky, Casey L Humphries, Nicholas L Aparicio, Mahak Sharma, James H Marden, Maria M Krasilnikova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Biomedicines · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Emmanuella O AjenuDepartment of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania, United states of America.
Ashley M SeideneckDepartment of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania, United states of America.
Esh PandellapalliDepartment of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania, United states of America.
Emily M ShinskyDepartment of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania, United states of America.
Casey L HumphriesDepartment of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania, United states of America.
Nicholas L AparicioDepartment of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania, United states of America.
Mahak SharmaDepartment of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania, United states of America.
James H MardenDepartment of Biology, Penn State University, University Park, Pennsylvania, United states of America.
Maria M KrasilnikovaDepartment of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania, United states of America.ORCID 0009-0008-9650-7151
Pennsylvania State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cigarette smoke-induced protein aggregation damages the lung cells in emphysema and COPD; however, lung cancer cells continue to thrive, evolving to persist in the toxic environment. Here, we showed that upon the cigarette smoke condensate exposure, A549 lung cancer cells exhibit better survival and reduced level of protein aggregation when compared to non-cancerous Beas-2B and H-6053 cells. Our data suggests that upregulation of efflux pumps in cancer cells assists in reducing smoke toxicity. Specifically, we demonstrated that inhibition of the ABCG2 transporter in A549 by febuxostat or its downregulation by shRNA-mediated RNA interference resulted in a significant increase in protein aggregation due to smoke exposure.

Indexed as

ATP Binding Cassette Transporter, Subfamily G, Member 2Cigarette SmokingLung NeoplasmsProtein AggregatesA549 CellsHumansNeoplasm ProteinsABCG2 protein, humanATP Binding Cassette Transporter, Subfamily G, Member 2Neoplasm ProteinsProtein Aggregates

Identifiers

PMID38442133
PMCPMC10914296
OpenAlexW4392454158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.