ArticleJournal of the American Chemical Society2024
Trinucleotide mRNA Cap Analogue
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Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Bioengineering strategies for improving the immunogenicity of mRNA vaccines.Signal transduction and targeted therapy · 2026Review
- RNA therapeutics: current status and future directions.Signal transduction and targeted therapy · 2026Review
- Circular Photocaged mRNA for Light-induced Late-stage Activation of Translation.Angewandte Chemie (International ed. in English) · 2026Article
- The current landscape of mRNA therapy and the strategies for mRNA purification and dsRNA removal.Journal of biomedical science · 2026Review
- Enhancement of Therapeutic mRNA Translation in Cellular Stress Conditions.International journal of molecular sciences · 2026Review
- FTO separation-of-function mutations alter mbioRxiv : the preprint server for biology · 2026Article
- Beyond the Sequence: Chemical and Topological Design and Innovations in mRNA Therapeutics.Chemical reviews · 2026Review
- The trypanosome mRNA decapping enzyme ALPH1 prefers caps without m7G methylation and produces diphosphate RNA.Nucleic acids research · 2026Article
- Novel trinucleotide mRNA capping reagents: improved synthetic route and efficient cotranscriptional incorporation in mRNA.RNA (New York, N.Y.) · 2026Article
- The 5' Cap Epitranscriptome and Beyond: Natural and Engineered 5' Cap Modifications for Optimizing mRNA Therapeutics and Functional Studies.ChemMedChem · 2026Review
- Synthesis, Incorporation, and Translation Properties of Threose Nucleic Acid Modified Trinucleotide Cap Analogs.ACS omega · 2025Article
- Advances and Strategies in Enhancing mRNA Cancer Vaccines.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Differential control of RNA demethylase activity and selectivity by cofactor ascorbate.bioRxiv : the preprint server for biology · 2025Article
- Revolutionizing immunization: a comprehensive review of mRNA vaccine technology and applications.Virology journal · 2025Review
- CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA.Molecular therapy. Nucleic acids · 2025Article
- 5' terminal nucleotide determines the immunogenicity of IVT RNAs.Nucleic acids research · 2025Article
- Discovery and development of a safe and efficient COVID-19 mRNA vaccine, STP2104, using a novel capping library screening method.Frontiers in immunology · 2025Article
- Development of hydrophobic tag purifying monophosphorylated RNA for chemical synthesis of capped mRNA and enzymatic synthesis of circular mRNA.Nucleic acids research · 2024Article
- Trinucleotide cap analogs with triphosphate chain modifications: synthesis, properties, and evaluation as mRNA capping reagents.Nucleic acids research · 2024Article
- mRNA medicine: Recent progresses in chemical modification, design, and engineering.Nano research · 2024Article
Corrections and comments
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Authors and funding
26 authors at 5 institutions in 2 countries.
Marcin WarminskiDivision of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, 02-089 Warsaw, Poland.ORCID 0000-0002-1071-3405
Edyta TrepkowskaExplorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland.
Miroslaw SmietanskiExplorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland.
Pawel J SikorskiCentre of New Technologies, University of Warsaw, 02-089 Warsaw, Poland.ORCID 0000-0001-9842-6533
Marek R BaranowskiExplorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland.ORCID 0000-0002-1426-482X
Marcelina BednarczykCentre of New Technologies, University of Warsaw, 02-089 Warsaw, Poland.ORCID 0000-0002-8246-1243
Hanna KedzierskaExplorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland.
Bartosz MajewskiExplorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland.
Adam MamotCentre of New Technologies, University of Warsaw, 02-089 Warsaw, Poland.
Diana PapiernikExplorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland.
Agnieszka PopielecExplorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland.
Remigiusz A SerwaProteomics Core Facility, IMol Polish Academy of Sciences, 02-247 Warsaw, Poland.
Brittany A ShimanskiDepartment of Chemistry & Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Piotr SklepkiewiczExplorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland.
Marta SkluckaExplorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland.
Olga SokolowskaExplorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland.
Tomasz SpiewlaDivision of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, 02-089 Warsaw, Poland.
Diana Toczydlowska-SochaExplorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland.
Zofia WarminskaCentre of New Technologies, University of Warsaw, 02-089 Warsaw, Poland.
Karol WolosewiczExplorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland.
Joanna ZuberekDivision of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, 02-089 Warsaw, Poland.
Jeffrey S MugridgeDepartment of Chemistry & Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Dominika NowisExplorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland.
Jakub GolabExplorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland.
Jacek JemielityCentre of New Technologies, University of Warsaw, 02-089 Warsaw, Poland.ORCID 0000-0001-7633-788X
Joanna KowalskaDivision of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, 02-089 Warsaw, Poland.ORCID 0000-0002-9174-7999
OncoArendi Therapeutics (Poland) · PLUniversity of Warsaw · PLMedical University of Warsaw · PLUniversity of Delaware · USPolish Academy of Sciences · PL
Funding
Chemistry-Biology Interface Predoctoral Training Grant 2024-2029T32GM133395 · NIGMS · UNIVERSITY OF DELAWARE · PI Catherine Leimkuhler Grimes · 2019 to 2026
$3.7MSelectivity and regulation of mRNA demethylation by iron-dependent dioxygenasesR35GM143000 · NIGMS · UNIVERSITY OF DELAWARE · PI MUGRIDGE, JEFFREY SCOTT · 2021 to 2025
$2.1MNIGMS NIH HHS R35 GM143000NIGMS NIH HHS T32 GM133395
Abstract
Eukaryotic mRNAs undergo cotranscriptional 5'-end modification with a 7-methylguanosine cap. In higher eukaryotes, the cap carries additional methylations, such as
Indexed as
RNA CapsVaccinesAnimalsMethylationMiceProtein BiosynthesisRNA, MessengerRNA CapsRNA, MessengerVaccines
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.