ArticleEuropean heart journal2024
Atrial secondary tricuspid regurgitation: pathophysiology, definition, diagnosis, and treatment.
Article in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 113 citations in OpenAlex.
- Tricuspid regurgitation: standardized stepwise work-up from referral to expert heart valve centre.European heart journal · 2026Review
- Combined transcatheter mitral and tricuspid edge-to-edge repair or tricuspid edge-to-edge repair alone in moderate mitral regurgitation: a propensity-matched analysis.European heart journal · 2026Article
- Combining MELD-XI score and hemodynamic parameters enhances short-term prognostic value in patients undergoing transcatheter tricuspid valve interventions.Wiener klinische Wochenschrift · 2026Article
- Myocardial remodeling in valvular heart disease: pathophysiology, multimodality imaging and treatment implications.Heart failure reviews · 2026Review
- Severe tricuspid regurgitation: aetiology, patient characteristics, and treatment: a multicentre, prospective registry.ESC heart failure · 2026Observational
- Combined Atrial Functional Mitral and Tricuspid Regurgitation in Atrial Fibrillation: Prevalence, Associated Factors, and Three-Dimensional Valve Remodeling.Journal of clinical medicine · 2026Article
- Prognostic Value of Right Atrial Strain in Patients With Moderate-to-Severe Tricuspid Regurgitation.Journal of the American Heart Association · 2026Article
- Tricuspid valve disease: updates on diagnostic imaging and intervention.Nature reviews. Cardiology · 2026Review
- Heart failure and tricuspid regurgitation: the role of SGLT2 inhibitors in improving outcomes.European heart journal. Cardiovascular pharmacotherapy · 2026Observational
- Tricuspid Regurgitation: Pathophysiology, Risk Stratification, and Implications for Intervention.Journal of clinical medicine · 2026Review
- The natural history of autosomal recessive atrial dilated cardiomyopathy associated with mutation of natriuretic peptide precursor A.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Prognosis of tricuspid regurgitation after mitral transcatheter edge-to-edge repair: the EXPANDed studies.ESC heart failure · 2026Observational
- A Novel Minimally Invasive Porcine Model of Functional Tricuspid Regurgitation.Journal of cardiovascular development and disease · 2026Article
- Comparison of Echocardiographic Right Ventricular-Pulmonary Arterial Coupling Indices in Patients Undergoing Transcatheter Tricuspid Valve Repair.Structural heart : the journal of the Heart Team · 2026Article
- Aetiology, prevalence, and prognosis.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Clinical and imaging phenotypes.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Advancement in pre- and peri-procedural imaging.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Sex differences in the prevalence and prognosis of tricuspid regurgitation among patients with heart failure.Heart (British Cardiac Society) · 2026Article
- Atrial Fibrillation and Tricuspid Regurgitation - Insights From a Transcatheter Aortic Valve Replacement Registry.Circulation reports · 2026Article
- Assessment of Right Ventricular Function Prior to Transcatheter Tricuspid Valve Interventions.Current cardiology reports · 2026Review
Corrections and comments
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Authors and funding
18 authors at 15 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atrial secondary tricuspid regurgitation (A-STR) is a distinct phenotype of secondary tricuspid regurgitation with predominant dilation of the right atrium and normal right and left ventricular function. Atrial secondary tricuspid regurgitation occurs most commonly in elderly women with atrial fibrillation and in heart failure with preserved ejection fraction in sinus rhythm. In A-STR, the main mechanism of leaflet malcoaptation is related to the presence of a significant dilation of the tricuspid annulus secondary to right atrial enlargement. In addition, there is an insufficient adaptive growth of tricuspid valve leaflets that become unable to cover the enlarged annular area. As opposed to the ventricular phenotype, in A-STR, the tricuspid valve leaflet tethering is typically trivial. The A-STR phenotype accounts for 10%-15% of clinically relevant tricuspid regurgitation and has better outcomes compared with the more prevalent ventricular phenotype. Recent data suggest that patients with A-STR may benefit from more aggressive rhythm control and timely valve interventions. However, little is mentioned in current guidelines on how to identify, evaluate, and manage these patients due to the lack of consistent evidence and variable definitions of this entity in recent investigations. This interdisciplinary expert opinion document focusing on A-STR is intended to help physicians understand this complex and rapidly evolving topic by reviewing its distinct pathophysiology, diagnosis, and multi-modality imaging characteristics. It first defines A-STR by proposing specific quantitative criteria for defining the atrial phenotype and for discriminating it from the ventricular phenotype, in order to facilitate standardization and consistency in research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.