ArticleEuropean journal of applied physiology2024
Cortical and spinal responses to short-term strength training and detraining in young and older adults in rectus femoris muscle.
Article in European journal of applied physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Age-Related Differences in Corticospinal Function and Muscle Strength: A Systematic Review and Meta-Analysis.The European journal of neuroscience · 2026Pooled it
- Six weeks of isometric resistance training led to evidence of corticospinal but not reticulospinal adaptation in previously untrained adult males.Experimental brain research · 2026Trial
- Translational perspectives on neurophysiological responses and mechanisms in blood flow restriction exercise.Experimental physiology · 2026Review
- Age-related differences in corticospinal and reticulospinal adaptations to short-term strength training.European journal of applied physiology · 2026Article
- Reticulospinal and corticospinal responses in long-term strength-trained and untrained adults.European journal of applied physiology · 2025Article
- Effects and mechanisms of resistance training on corticospinal adaptation.Frontiers in physiology · 2025Review
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionStrength training mitigates the age-related decline in strength and muscle activation but limited evidence exists on specific motor pathway adaptations.
methodsEleven young (22-34 years) and ten older (66-80 years) adults underwent five testing sessions where lumbar-evoked potentials (LEPs) and motor-evoked potentials (MEPs) were measured during 20 and 60% of maximum voluntary contraction (MVC). Ten stimulations, randomly delivered, targeted 25% of maximum compound action potential for LEPs and 120, 140, and 160% of active motor threshold (aMT) for MEPs. The 7-week whole-body resistance training intervention included five exercises, e.g., knee extension (5 sets) and leg press (3 sets), performed twice weekly and was followed by 4 weeks of detraining.
resultsYoung had higher MVC (~ 63 N·m, p = 0.006), 1-RM (~ 50 kg, p = 0.002), and lower aMT (~ 9%, p = 0.030) than older adults at baseline. Young increased 1-RM (+ 18 kg, p < 0.001), skeletal muscle mass (SMM) (+ 0.9 kg, p = 0.009), and LEP amplitude (+ 0.174, p < 0.001) during 20% MVC. Older adults increased MVC (+ 13 N·m, p = 0.014), however, they experienced decreased LEP amplitude (- 0.241, p < 0.001) during 20% MVC and MEP amplitude reductions at 120% (- 0.157, p = 0.034), 140% (- 0.196, p = 0.026), and 160% (- 0.210, p = 0.006) aMT during 60% MVC trials. After detraining, young and older adults decreased 1-RM, while young adults decreased SMM.
conclusionHigher aMT and MEP amplitude in older adults were concomitant with lower baseline strength. Training increased strength in both groups, but divergent modifications in cortico-spinal activity occurred. Results suggest that the primary locus of adaptation occurs at the spinal level.
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