Evidence map›Paper›PMID 38441684›Full record

ArticleMikrochimica acta2024

Point-of-care detection of Monkeypox virus clades using high-performance upconversion nanoparticle-based lateral flow assay.

Birui Jin, Chuan Ma, Chuyao Zhang, Huiling Yin, Guoxu Zhao, Jie Hu, Zedong Li

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mpox disease, diagnosis, and point of care platforms.Bioengineering & translational medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Birui JinSchool of Materials and Chemical Engineering, Xi'an Technological University, Xi'an, 710021, People's Republic of China.
Chuan MaSchool of Materials and Chemical Engineering, Xi'an Technological University, Xi'an, 710021, People's Republic of China.
Chuyao ZhangSchool of Materials and Chemical Engineering, Xi'an Technological University, Xi'an, 710021, People's Republic of China.
Huiling YinBioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.
Guoxu ZhaoBioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.
Jie HuSuzhou DiYinAn Biotech Co., Ltd., Suzhou Innovation Center for Life Science and Technology, Suzhou, 215129, People's Republic of China. jason.hu@sz-dna.cn.
Zedong LiKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, People's Republic of China. zedong@xjtu.edu.cn.

Funding

General Financial Grant from the China Postdoctoral Science Foundation 2020M673418National Natural Science Foundation of China 61904143Opening Research Fund from Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University 2019LHM-KFKT005the Natural Science Foundation of the Anhui Higher Education Institutions of China KJ2021ZD0150
6 · The paper itself

Abstract

There is an urgent need for a point-of-care testing (POCT) method in developing and underserved regions to distinguish between two Monkeypox virus (MPXV) clades, given their varying transmissibility and clinical manifestations. In this paper, we target the specific complement protein gene fragment of two MPXV clades and construct a high-performance upconversion nanoparticles-based lateral flow assay (UCNPs-based LFA) with double T-lines and a shared C-line. This enables qualitative and quantitative dual-mode detection when combined with a smartphone and a benchtop fluorescence analyzer. The developed LFA exhibits stable performance, convenient operation, rapid readout (within 8 min), and a much lower limit of detection (LOD) (~ pM level) compared to existing POCT methods. The proposed detection platform demonstrates significant potential for pathogen diagnosis using a POCT approach.

Indexed as

NanoparticlesPoint-of-Care SystemsLimit of DetectionMonkeypox virusMpox, MonkeypoxPoint-of-Care TestingFluorescenceLateral flow assayMonkeypox virusNucleic acid detectionPoint-of-care testing

Identifiers

PMID38441684

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.