ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2024
Association of spinal cord abnormalities with vertebral anomalies: an embryological perspective.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 4 citations in OpenAlex.
- One-stage posterior-only radical hemivertebra resection and short-segment fusion for congenital cervicothoracic scoliosis: a cohort study.BMC surgery · 2026Article
- A rare case of intradural intramedullary cervical spinal neurenteric cyst in an adult: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
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3 authors at 1 institution in 1 country.
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Abstract
purposeTo analyze the relationship between spinal cord and vertebral abnormalities from the point of view of embryology.
methodsWe analyzed the clinical and radiological data of 260 children with different types of spinal cord malformations in combination with vertebral abnormalities.
resultsAmong 260 individuals, approximately 109 presented with open neural tube defects (ONTDs), 83 with split cord malformations (SCMs), and 83 with different types of spinal lipomas. Pathological spina bifida emerged as the most frequent vertebral anomaly, affecting 232 patients, with a higher prevalence in ONTD. Vertebral segmentation disorders, including unsegmented bars, butterfly vertebrae, and hemivertebrae, were present in 124 cases, with a higher prevalence in SCM. The third most common spinal anomaly group consisted of various forms of sacral agenesis (58 cases), notably associated with blunt conus medullaris, spinal lipomas, and sacral myelomeningocele. Segmental aplasia of the spinal cord had a typical association with segmental spinal absence (N = 17).
conclusionThe association between SCM and neuroenteric cyst/canal and vertebral segmentation disorders is strong. High ONTDs often coincide with pathological spina bifida posterior. Type 1 spinal lipomas and focal spinal nondisjunction also correlate with pathologic spina bifida. Segmental spinal absence or dysgenesis involves localized spinal and spinal cord aplasia, sometimes with secondary filar lipoma.
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