ArticleeLife2024
Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse.
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Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 13 citations in OpenAlex.
- Loss-of-function mutations in Ccdc113 cause male infertility in both humans and mice.Asian journal of andrology · 2026Article
- Molecular interplay between sperm and oocyte: a narrative review.Human reproduction update · 2026Review
- Sequencing the CCDC146 gene in a large cohort of infertile Chinese men reveals novel mutations in patients with asthenoteratozoospermia.Chinese medical journal · 2026Article
- Human Sperm Centrosome: From Current Evidence to Future Perspectives-A Systematic Review.Life (Basel, Switzerland) · 2026Review
- Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2-EZH2-Mediated Microtubule Destabilization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Of mice and men: translating mouse knockout models of human male infertility.Reproduction (Cambridge, England) · 2025Review
- Antisense oligonucleotide depletion ofmedRxiv : the preprint server for health sciences · 2025Article
- Introduction to androgenetics: terminology, approaches, and impactful studies across 60 years.Andrology · 2025Review
- Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies.Andrology · 2025Review
- Exploring the therapeutic effect of melatonin targeting common biomarkers in testicular germ cell tumor, prostate adenocarcinoma, and male infertility: an integrated biology approach.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Function of manchette and intra-manchette transport in spermatogenesis and male fertility.Cell communication and signaling : CCS · 2025Review
- Reproductive health.eLife · 2025Article
- HomozygousZoological research · 2024Article
- The MBO2/FAP58 heterodimer stabilizes assembly of inner arm dyneinMolecular biology of the cell · 2024Article
- CCDC146 is required for sperm flagellum biogenesis and male fertility in mice.Cellular and molecular life sciences : CMLS · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 2 institutions in 4 countries.
Jana Muroňová *Institute for Advanced Biosciences (IAB), INSERM 1209, Grenoble, France.ORCID https://orcid.org/0009-0002-3433-4028
Zine Eddine Kherraf *Institute for Advanced Biosciences (IAB), INSERM 1209, Grenoble, France.
Elsa GiordaniInstitute for Advanced Biosciences (IAB), INSERM 1209, Grenoble, France.
Emeline LambertInstitute for Advanced Biosciences (IAB), INSERM 1209, Grenoble, France.
Simon EckertCell Biology/ Electron Microscopy, University of Bayreuth, Bayreuth, Germany.
Caroline CazinInstitute for Advanced Biosciences (IAB), INSERM 1209, Grenoble, France.
Amir Amiri-YektaInstitute for Advanced Biosciences (IAB), INSERM 1209, Grenoble, France.
Magali CourtInstitute for Advanced Biosciences (IAB), INSERM 1209, Grenoble, France.
Geneviève ChevalierInstitute for Advanced Biosciences (IAB), INSERM 1209, Grenoble, France.
Guillaume MartinezInstitute for Advanced Biosciences (IAB), INSERM 1209, Grenoble, France.ORCID https://orcid.org/0000-0002-7572-9096
Yasmine NeirijnckDepartment of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
Francoise KühneDepartment of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
Lydia WehrliDepartment of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.ORCID https://orcid.org/0000-0003-1132-9699
Nikolai KlenaUniversity of Geneva, Department of Molecular and Cellular Biology, Sciences III, Geneva, Switzerland.
Virginie HamelUniversity of Geneva, Department of Molecular and Cellular Biology, Sciences III, Geneva, Switzerland.ORCID https://orcid.org/0000-0001-5092-2343
Lisa De MacedoInstitute for Advanced Biosciences (IAB), INSERM 1209, Grenoble, France.
Jessica EscoffierInstitute for Advanced Biosciences (IAB), INSERM 1209, Grenoble, France.ORCID https://orcid.org/0000-0001-8166-5845
Paul GuichardUniversity of Geneva, Department of Molecular and Cellular Biology, Sciences III, Geneva, Switzerland.ORCID https://orcid.org/0000-0002-0363-1049
Charles CouttonInstitute for Advanced Biosciences (IAB), INSERM 1209, Grenoble, France.ORCID https://orcid.org/0000-0002-8873-8098
Selima Fourati Ben MustaphaPolyclinique les Jasmins, Centre d'Aide Médicale à la Procréation, Centre Urbain Nord, Tunis, Tunisia.
Mahmoud KharoufPolyclinique les Jasmins, Centre d'Aide Médicale à la Procréation, Centre Urbain Nord, Tunis, Tunisia.
Anne-Pacale BouinInstitute for Advanced Biosciences (IAB), INSERM 1209, Grenoble, France.
Raoudha ZouariPolyclinique les Jasmins, Centre d'Aide Médicale à la Procréation, Centre Urbain Nord, Tunis, Tunisia.
Nicolas Thierry-MiegLaboratoire TIMC/MAGe, CNRS UMR 5525, Pavillon Taillefer, Faculté de Medecine, La Tronche, France.ORCID https://orcid.org/0000-0002-7667-2853
Serge NefDepartment of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.ORCID https://orcid.org/0000-0001-5462-0676
Stefan GeimerCell Biology/ Electron Microscopy, University of Bayreuth, Bayreuth, Germany.
Corinne LoeuilletInstitute for Advanced Biosciences (IAB), INSERM 1209, Grenoble, France.
Pierre F RayInstitute for Advanced Biosciences (IAB), INSERM 1209, Grenoble, France.
Christophe ArnoultInstitute for Advanced Biosciences (IAB), INSERM 1209, Grenoble, France.ORCID https://orcid.org/0000-0002-3753-5901
University of Geneva · CHInserm · FR
Funding
European Research Council 715289
Abstract
From a cohort of 167 infertile patients suffering from multiple morphological abnormalities of the flagellum (MMAF), pathogenic bi-allelic mutations were identified in the
Indexed as
Abnormalities, MultipleInfertility, MaleAnimalsCentriolesHumansMaleMiceMice, KnockoutMicrotubule-Associated ProteinsSemenCCDC146 protein, humanMicrotubule-Associated Proteinscell biologyflagellumgeneticsgenomicshumaninfertilitymousesperm
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.