Evidence map›Paper›PMID 38441219›Full record

ArticleScandinavian journal of immunology2024

IgG exacerbates genital chlamydial pathology in females by enhancing pathogenic CD8

Charles W Armitage, Connor P O'Meara, Emily R Bryan, Avinash Kollipara, Logan K Trim, Danica Hickey, Alison J Carey, Wilhelmina M Huston, Gavin Donnelly, Anusch Yazdani and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scandinavian journal of immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Charles W ArmitageCentre for Immunology and Infection Control and School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
Connor P O'MearaCentre for Immunology and Infection Control and School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
Emily R BryanCentre for Immunology and Infection Control and School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0002-8912-6878
Avinash KolliparaCentre for Immunology and Infection Control and School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
Logan K TrimCentre for Immunology and Infection Control and School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
Danica HickeyCentre for Immunology and Infection Control and School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
Alison J CareyCentre for Immunology and Infection Control and School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
Wilhelmina M HustonSchool of Life Sciences, University of Technology (UTS) Sydney, Ultimo, New South Wales, Australia.
Gavin DonnellyQueensland Fertility Group (QFG), Brisbane, Queensland, Australia.
Anusch YazdaniQueensland Fertility Group (QFG), Brisbane, Queensland, Australia.
Richard S BlumbergDivision of Gastroenterology, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Kenneth W BeagleyCentre for Immunology and Infection Control and School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
Queensland University of Technology · AUQueensland Rail · AUBrigham and Women's Hospital · USUniversity of Technology Sydney · AU

Funding

National Health and Medical Research Council 1049571
6 · The paper itself

Abstract

Chlamydia trachomatis infections are an important sexually transmitted infection that can lead to inflammation, scarring and hydrosalpinx/infertility. However, infections are commonly clinically asymptomatic and do not receive treatment. The underlying cause of asymptomatic immunopathology remains unknown. Here, we demonstrate that IgG produced during male infection enhanced the incidence of immunopathology and infertility in females. Human endocervical cells expressing the neonatal Fc Receptor (FcRn) increased translocation of human IgG-opsonized C. trachomatis. Using total IgG purified from infected male mice, we opsonized C. muridarum and then infected female mice, mimicking sexual transmission. Following infection, IgG-opsonized Chlamydia was found to transcytose the epithelial barrier in the uterus, where it was phagocytosed by antigen-presenting cells (APCs) and trafficked to the draining lymph nodes. APCs then expanded both CD4

Indexed as

ChlamydiaInfertilityAnimalsCD8-Positive T-LymphocytesFemaleGenitaliaHumansImmunoglobulin GMaleMiceImmunoglobulin GasymptomaticChlamydiaFcRnIgGtransmission

Identifiers

PMID38441219
PMCPMC10909563
OpenAlexW4387640908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.