Evidence map›Paper›PMID 38441140›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2024

Nuclear Medicine Imaging Tools in Fever of Unknown Origin: Time for a Revisit and Appropriate Use Criteria.

William F Wright, Sheetal Kandiah, Rebecca Brady, Barry L Shulkin, Christopher J Palestro, Sanjay K Jain

Open access · bronzeAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. State-of-the-Art Review: Contemporary Ambulatory Approach to Adult Fever of Unknown Origin.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Review
  3. Role ofJournal of clinical medicine · 2025
    Review
  4. DynamicAmerican journal of respiratory and critical care medicine · 2025
    Observational
  5. Article
  6. Interest ofJournal of clinical medicine · 2025
    Article
  7. Performance and value ofBiomedical reports · 2024
    Article
  8. Article
  9. What Is the Role of [Open forum infectious diseases · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

William F WrightDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Sheetal KandiahDepartment of Medicine, Division of Infectious Diseases, Emory University Hospital, Atlanta, Georgia, USA.
Rebecca BradyCincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Barry L ShulkinDiagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Christopher J PalestroDepartment of Radiology, Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
Sanjay K JainCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-9620-7070
Johns Hopkins University · USCincinnati Children's Hospital Medical Center · USEmory University Hospital · USHofstra University · USSt. Jude Children's Research Hospital · US

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Preclinical modeling to study Tuberculous MeningitisR01AI145435 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$4.0M
Measuring Intralesional Drug Exposures in Cavitary TB using Noninvasive In Vivo PET ImagingR01AI153349 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$3.8M
Development of 11C-PABA as a bacteria-specific imaging agent for spinal infectionsR01EB025985 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAIN, SANJAY, WILSON, DAVID M · 2018 to 2021
$2.7M
Measuring Intralesional Bedaquiline Exposures in Cavitary TB Using Noninvasive In Vivo PET ImagingR21AI149760 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY, ORDONEZ, ALVARO ANDRES · 2020 to 2021
$450k
Johns Hopkins Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases R01-AI145435-A1NCATS NIH HHS UL1 TR003098NIAID NIH HHS R01 AI145435NIAID NIH HHS R01 AI153349NIAID NIH HHS R21 AI149760NIBIB NIH HHS R01 EB025985NIH HHS
6 · The paper itself

Abstract

Fever of unknown origin (FUO) is a clinical conundrum for patients and clinicians alike, and imaging studies are often performed as part of the diagnostic workup of these patients. Recently, the Society of Nuclear Medicine and Molecular Imaging convened and approved a guideline on the use of nuclear medicine tools for FUO. The guidelines support the use of 2-18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) in adults and children with FUO. 18F-FDG PET/CT allows detection and localization of foci of hypermetabolic lesions with high sensitivity because of the 18F-FDG uptake in glycolytically active cells that may represent inflammation, infection, or neoplasia. Clinicians should consider and insurers should cover 18F-FDG PET/CT when evaluating patients with FUO, particularly when other clinical clues and preliminary studies are unrevealing.

Indexed as

Fever of Unknown OriginFluorodeoxyglucose F18Nuclear MedicinePositron Emission Tomography Computed TomographyAdultChildHumansPractice Guidelines as TopicRadiopharmaceuticalsFluorodeoxyglucose F18Radiopharmaceuticalsfeverfever of unknown originnuclear medicinepyrexiapyrexia of unknown origin

Identifiers

PMID38441140
PMCPMC11093677
OpenAlexW4392457733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.