ArticleEnvironmental science & technology2024
Plastic Food Packaging from Five Countries Contains Endocrine- and Metabolism-Disrupting Chemicals.
Article in Environmental science & technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Potential association between endocrine disrupting chemicals (EDCs) and gynecomastia: a systematic review based on partial experimental evidenceendocrine-disrupting chemicals.Frontiers in endocrinology · 2026Pooled it
- Microplastics at the Intersection of Toxicology, Child Health, and Human Rights.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- The Gut-brain-adipose Axis in Ultra-processed Food and Obesity: A Mechanistic Synthesis and Its Implications for Food Classification.Current obesity reports · 2026Review
- Thermodynamic and Structural Insights into Endocrine Disruptor Adsorption.The journal of physical chemistry. C, Nanomaterials and interfaces · 2026Article
- Oil-Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Environmental occurrence, exposure, toxicity, and transformation of benzothiazoles: A review.Eco-Environment & Health · 2026Review
- Identifying Food Packaging Migrants: Current Analytical Capabilities, Challenges, and Future Prospects.Comprehensive reviews in food science and food safety · 2026Review
- Potential Role of Mosses in Evaluating Airborne Microplastic Deposition in Terrestrial Ecosystems.Journal of xenobiotics · 2026Review
- Article
- Toxic threats from plastic waste: human health impacts, challenges, and policy solutions.RSC advances · 2025Review
- Microplastics and the Rising Tide of Early-Onset Colorectal Cancer: Exploring the Environmental Gut Connection.ANZ journal of surgery · 2025Article
- Beyond Estrogenicity: A Comparative Assessment of Bisphenol A and Its Alternatives in In Vitro Assays Questions Safety of Replacements.Environmental science & technology · 2025Article
- A Hazard-Based Approach Enables the Efficient Identification of Chemicals of Concern in Plastics.Environmental science & technology · 2025Review
- Autism Spectrum Disorder as a Multifactorial Disorder: The Interplay of Genetic Factors and Inflammation.International journal of molecular sciences · 2025Review
- A simulation study on the temperature-dependent release of endocrine-disrupting chemicals from polypropylene and polystyrene containers.Scientific reports · 2025Article
- Exploring the Complexities of Seafood: From Benefits to Contaminants.Foods (Basel, Switzerland) · 2025Review
- Burnt Plastic (Pyroplastic) from the M/VEnvironment & health (Washington, D.C.) · 2025Article
- Hazard identification and characterization of leachable chemicals from plastic products - a new PARC project.Frontiers in toxicology · 2025Article
- Microplastic Exposure and Its Dual Impact on Metabolic Syndrome and Pathways of Colorectal Carcinogenesis: A Systematic Review of Epidemiological, Experimental, and Mechanistic Evidence.Journal of toxicology · 2025Review
- How do plastics, including microplastics and plastic-associated chemicals, affect human health?Nature medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plastics are complex chemical mixtures of polymers and various intentionally and nonintentionally added substances. Despite the well-established links between certain plastic chemicals (bisphenols and phthalates) and adverse health effects, the composition and toxicity of real-world mixtures of plastic chemicals are not well understood. To assess both, we analyzed the chemicals from 36 plastic food contact articles from five countries using nontarget high-resolution mass spectrometry and reporter-gene assays for four nuclear receptors that represent key components of the endocrine and metabolic system. We found that chemicals activating the pregnane X receptor (PXR), peroxisome proliferator receptor γ (PPARγ), estrogen receptor α (ERα), and inhibiting the androgen receptor (AR) are prevalent in plastic packaging. We detected up to 9936 chemical features in a single product and found that each product had a rather unique chemical fingerprint. To tackle this chemical complexity, we used stepwise partial least-squares regressions and prioritized and tentatively identified the chemical features associated with receptor activity. Our findings demonstrate that most plastic food packaging contains endocrine- and metabolism-disrupting chemicals. Since samples with fewer chemical features induce less toxicity, chemical simplification is key to producing safer plastic packaging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.