Evidence map›Paper›PMID 38440987›Full record

ArticleACS chemical neuroscience2024

4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H

Beata Michalska, Marek Dzięgielewski, Justyna Godyń, Tobias Werner, Marek Bajda, Tadeusz Karcz, Katarzyna Szczepańska, Holger Stark, Anna Więckowska, Krzysztof Walczyński and 1 more

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Beata MichalskaDepartment of Synthesis and Technology of Drugs, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
Marek DzięgielewskiDepartment of Synthesis and Technology of Drugs, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
Justyna GodyńDepartment of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.ORCID 0000-0002-0295-2772
Tobias WernerInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany.
Marek BajdaDepartment of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.ORCID 0000-0001-6032-0354
Tadeusz KarczDepartment of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Katarzyna SzczepańskaDepartment of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.ORCID 0000-0002-6110-9400
Holger StarkInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany.ORCID 0000-0003-3336-1710
Anna WięckowskaDepartment of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.ORCID 0000-0003-2549-170X
Krzysztof WalczyńskiDepartment of Synthesis and Technology of Drugs, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
Marek StaszewskiDepartment of Synthesis and Technology of Drugs, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.ORCID 0000-0003-2783-522X
Jagiellonian University · PLMedical University of Lodz · PLHeinrich Heine University Düsseldorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study examines the properties of a novel series of 4-oxypiperidines designed and synthesized as histamine H

Indexed as

CholinesterasesReceptors, Histamine H3Cholinesterase InhibitorsDrug Inverse AgonismEthersHistamineLigandsMolecular StructureReceptors, HistamineStructure-Activity RelationshipCholinesterase InhibitorsCholinesterasesEthersHistamineLigandsReceptors, HistamineReceptors, Histamine H3acetylcholinestrase inhibitorbutyrylcholinesterase inhibitorhistamine H3 receptormultiple targetingneurodegenerative diseasepolypharmacology

Identifiers

PMID38440987
PMCPMC10958501
OpenAlexW4392458155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.