Evidence map›Paper›PMID 38440827›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2024

Hepatic LGR4 aggravates cholestasis-induced liver injury in mice.

Yuan Gao, Wenbo Zhai, Lijun Sun, Xueqian Du, Xianfeng Wang, Michael W Mulholland, Yue Yin, Weizhen Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yuan GaoDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing, People's Republic of China.
Wenbo ZhaiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing, People's Republic of China.
Lijun SunDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing, People's Republic of China.
Xueqian DuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing, People's Republic of China.
Xianfeng WangDepartment of Pharmacology, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing, People's Republic of China.
Michael W MulhollandDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, United States.
Yue YinDepartment of Pharmacology, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing, People's Republic of China.
Weizhen ZhangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing, People's Republic of China.ORCID 0000-0001-8791-2798
Peking University · CNUniversity of Michigan · US

Funding

The mTOR-ETV5 signaling in gastric X/A like cells and its role in hepatic lipid metabolism and steatosisR01DK129360 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEELEY, RANDY J · 2021 to 2024
$2.4M
R-spondin1-LGR4 Signaling and Ischemia/Reperfusion Injury in Steatotic LiverR01DK110273 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MULHOLLAND, MICHAEL W., ZHANG, WEIZHEN · 2017 to 2021
$2.1M
Gastric X/A Like Cells in Health and DiseasesR01DK112755 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEELEY, RANDY J · 2018 to 2022
$1.6M
HHS | National Institutes of Health (NIH) 1R01DK110273HHS | National Institutes of Health (NIH) 1R01DK129360HHS | National Institutes of Health (NIH) R01DK112755MOST | National Natural Science Foundation of China (NSFC) 81930015MOST | National Natural Science Foundation of China (NSFC) 82070592NIDDK NIH HHS R01 DK110273NIDDK NIH HHS R01 DK112755NIDDK NIH HHS R01 DK129360
6 · The paper itself

Abstract

Current therapy for hepatic injury induced by the accumulation of bile acids is limited. Leucine-rich repeat G protein-coupled receptor 4 (LGR4), also known as GPR48, is critical for cytoprotection and cell proliferation. Here, we reported a novel function for the LGR4 in cholestatic liver injury. In the bile duct ligation (BDL)-induced liver injury model, hepatic LGR4 expression was significantly downregulated. Deficiency of LGR4 in hepatocytes (

Indexed as

Chemical and Drug Induced Liver Injury, ChronicCholestasisAnimalsBile Acids and SaltsBile DuctsHepatocytesLigationLiverMiceProto-Oncogene Proteins c-aktReceptors, G-Protein-CoupledBile Acids and SaltsLGR4 protein, mouseProto-Oncogene Proteins c-aktReceptors, G-Protein-Coupledcholestatic liver diseasehepatocytesLGR4macrophagesS1PR2

Identifiers

PMID38440827
PMCPMC11213478
OpenAlexW4392470588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.