Evidence map›Paper›PMID 38440733›Full record

ReviewFrontiers in immunology2024

Leprosy: treatment, prevention, immune response and gene function.

Xiang Li, Yun Ma, Guoli Li, Guangjie Jin, Li Xu, Yunhui Li, Pingmin Wei, Lianhua Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  8. The Role ofInternational journal of molecular sciences · 2025
    Review
  9. Unraveling Drug Resistance inInternational journal of microbiology · 2025
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xiang Li *Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Yun Ma *Chronic Infectious Disease Control Section, Nantong Center for Disease Control and Prevention, Nantong, China.
Guoli LiDepartment of Chronic Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Guangjie JinDepartment of Chronic Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Li XuDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Yunhui LiDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Pingmin WeiDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Lianhua ZhangDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Southeast University · CNJiangsu Provincial Center for Disease Control and Prevention · CNNantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the leprosy cases have fallen dramatically, the incidence of leprosy has remained stable over the past years, indicating that multidrug therapy seems unable to eradicate leprosy. More seriously, the emergence of rifampicin-resistant strains also affects the effectiveness of treatment. Immunoprophylaxis was mainly carried out through vaccination with the BCG but also included vaccines such as LepVax and MiP. Meanwhile, it is well known that the infection and pathogenesis largely depend on the host's genetic background and immunity, with the onset of the disease being genetically regulated. The immune process heavily influences the clinical course of the disease. However, the impact of immune processes and genetic regulation of leprosy on pathogenesis and immunological levels is largely unknown. Therefore, we summarize the latest research progress in leprosy treatment, prevention, immunity and gene function. The comprehensive research in these areas will help elucidate the pathogenesis of leprosy and provide a basis for developing leprosy elimination strategies.

Indexed as

Leprostatic AgentsLeprosyDrug Therapy, CombinationHumansImmunityRifampinLeprostatic AgentsRifampinimmune cellsleprosyMDTprophylaxisrifapentinesusceptibility gene

Identifiers

PMID38440733
PMCPMC10909994
OpenAlexW4391928880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.