Evidence map›Paper›PMID 38440322›Full record

ArticleBioactive materials2024

Combination of disulfiram and Copper-Cysteamine nanoparticles induces mitochondria damage and promotes apoptosis in endometrial cancer.

Lijun Yang, Cancan Yao, Zhenning Su, Yihao Fang, Nil Kanatha Pandey, Eric Amador, Tian Diao, Guo Bao, Derong Cao, Xihua Chen and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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  17. Copper homeostasis and cuproptosis in gynecological cancers.Frontiers in cell and developmental biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Lijun YangChinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
Cancan YaoChinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
Zhenning SuChinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
Yihao FangState Key Laboratory of Luminescent Materials and Devices, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, China.
Nil Kanatha PandeySchool of CHIPS, Xian-Jiaotong Liverpool University, Suzhou 215123, China.
Eric AmadorSchool of CHIPS, Xian-Jiaotong Liverpool University, Suzhou 215123, China.
Tian DiaoChinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
Guo BaoNHC Key Laboratory of Reproductive Health Engineering Technology Research, Department of Reproduction and Physiology, National Research Institute for Family Planning, Beijing 100081, China.
Derong CaoState Key Laboratory of Luminescent Materials and Devices, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, China.
Xihua ChenNHC Key Laboratory of Reproductive Health Engineering Technology Research, Department of Reproduction and Physiology, National Research Institute for Family Planning, Beijing 100081, China.
Xiangbo XuNHC Key Laboratory of Reproductive Health Engineering Technology Research, Department of Reproduction and Physiology, National Research Institute for Family Planning, Beijing 100081, China.
Bin HeNHC Key Laboratory of Reproductive Health Engineering Technology Research, Department of Reproduction and Physiology, National Research Institute for Family Planning, Beijing 100081, China.
Yufeng ZhengChinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
Wei ChenSchool of CHIPS, Xian-Jiaotong Liverpool University, Suzhou 215123, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNNational Health and Family Planning Commission · CNThe University of Texas at Arlington · USSouth China University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometrial cancer (EC) stands as one of the most prevalent gynecological malignancies affecting women, with its incidence and disease-related mortality steadily on the rise. Disulfiram (DSF), an FDA-approved medication primarily used for treating alcohol addiction, has exhibited promising anti-tumor properties. Studies have revealed DSF's capacity for enhanced anti-tumor activity, particularly when combined with copper. The novel Copper-Cysteamine (CuCy) compound, Cu

Indexed as

CombinationCopper−Cysteamine nanoparticlesDisulfiramMitochondria damagePromotes apoptosis in Endometrial Cancer

Identifiers

PMID38440322
PMCPMC10911931
OpenAlexW4392438490

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.