Evidence map›Paper›PMID 38440170›Full record

ArticleBeilstein journal of organic chemistry2024

Synthesis of 2,2-difluoro-1,3-diketone and 2,2-difluoro-1,3-ketoester derivatives using fluorine gas.

Alexander S Hampton, David R W Hodgson, Graham McDougald, Linhua Wang, Graham Sandford

Open access · diamondAbstract read
In one paragraph

Article in Beilstein journal of organic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Alexander S HamptonDurham University, Department of Chemistry, Lower Mountjoy, South Road, Durham, DH1 3LE, UK.
David R W HodgsonDurham University, Department of Chemistry, Lower Mountjoy, South Road, Durham, DH1 3LE, UK.ORCID https://orcid.org/0000-0003-4517-9166
Graham McDougaldSyngenta, Huddersfield Manufacturing Centre, PO Box A38, Huddersfield, West Yorkshire, HD2 1FF, UK.
Linhua WangSyngenta USA, 410 Swing Road, Greensboro, North Carolina, NC 27409, USA.
Graham SandfordDurham University, Department of Chemistry, Lower Mountjoy, South Road, Durham, DH1 3LE, UK.
Durham University · GBSyngenta (United States) · USUniversity of Huddersfield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Solutions of 1,3-diketones and 1,3-ketoester derivatives react with fluorine to give the corresponding 2,2-difluoro-1,3-dicarbonyl derivatives in the presence of quinuclidine. Quinuclidine reacts with fluorine in situ to generate a fluoride ion that facilitates limiting enolization processes, and an electrophilic N-F fluorinating agent that is reactive towards neutral enol species.

Indexed as

difluorinationdifluoromethylenedirect fluorinationelectrophilic fluorinationorganofluorine

Identifiers

PMID38440170
PMCPMC10910478
OpenAlexW4392237769

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.