Evidence map›Paper›PMID 38439958›Full record

ArticleiScience2024

Linda Voogd, Anne M H F Drittij, Calinda K E Dingenouts, Kees L M C Franken, Vincent van Unen, Krista E van Meijgaarden, Paula Ruibal, Renate S Hagedoorn, Judith A Leitner, Peter Steinberger and 5 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Advances in Single-Cell Sequencing for Infectious Diseases: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  4. Article
  5. Article
  6. Vaccines · 2024
    Article
  7. bioRxiv : the preprint server for biology · 2024
    Article
  8. HLA-E/Frontiers in immunology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Linda VoogdDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Anne M H F DrittijDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Calinda K E DingenoutsDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Kees L M C FrankenDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Vincent van UnenInstitute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Palo Alto, CA, USA.
Krista E van MeijgaardenDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Paula RuibalDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Renate S HagedoornDepartment of Hematology, Leiden University Medical Center, Leiden, the Netherlands.
Judith A LeitnerCentre for Pathophysiology, Infectiology and Immunology, Institute of Immunology, Medical University of Vienna, Vienna, Austria.
Peter SteinbergerCentre for Pathophysiology, Infectiology and Immunology, Institute of Immunology, Medical University of Vienna, Vienna, Austria.
Mirjam H M HeemskerkDepartment of Hematology, Leiden University Medical Center, Leiden, the Netherlands.
Mark M DavisInstitute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Palo Alto, CA, USA.
Thomas J ScribaSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Tom H M OttenhoffDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Simone A JoostenDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Leiden University Medical Center · NLMedical University of Vienna · ATSouth African Tuberculosis Vaccine Initiative · ZA

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
HLA-E restricted T-cell immunity in Mycobacterium tuberculosis infectionR01AI141315 · NIAID · LEIDEN UNIVERSITY MEDICAL CENTER · PI JOOSTEN, SIMONE ANNE · 2019 to 2022
$1.7M
In depth characterization of Mtb specific HLA-E restricted human CD8+ T-cellsR21AI127133 · NIAID · LEIDEN UNIVERSITY MEDICAL CENTER · PI OTTENHOFF, TOM · 2016 to 2017
$281k
NIAID NIH HHS R01 AI141315NIAID NIH HHS R21 AI127133NIAID NIH HHS U19 AI057229
6 · The paper itself

Abstract

HLA-E molecules can present self- and pathogen-derived peptides to both natural killer (NK) cells and T cells. T cells that recognize HLA-E peptides via their T cell receptor (TCR) are termed donor-unrestricted T cells due to restricted allelic variation of HLA-E. The composition and repertoire of HLA-E TCRs is not known so far. We performed TCR sequencing on CD8

Indexed as

GenotypingImmunologyTranscriptomics

Identifiers

PMID38439958
PMCPMC10909886
OpenAlexW4391847912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.