Evidence map›Paper›PMID 38439688›Full record

ReviewFEBS letters2024

A life-time of hematopoietic cell function: ascent, stability, and decline.

Anna Popravko, Lorna Mackintosh, Elaine Dzierzak

Open access · hybridAbstract readReview
In one paragraph

Review in FEBS letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anna PopravkoInstitute for Regeneration and Repair, University of Edinburgh, UK.
Lorna MackintoshInstitute for Regeneration and Repair, University of Edinburgh, UK.
Elaine DzierzakInstitute for Regeneration and Repair, University of Edinburgh, UK.ORCID https://orcid.org/0000-0001-8256-5635
MRC Centre for Regenerative Medicine · GB

Funding

Bloodwise/Blood Cancer UK Project Grant 18010European Research Council Advanced Grant 341096Wellcome TrustWellcome Trust PhD Training Fellowship for CliniciansWellcome Trust Tissue Repair PhD Training Programme
6 · The paper itself

Abstract

Aging is a set of complex processes that occur temporally and continuously. It is generally a unidirectional progression of cellular and molecular changes occurring during the life stages of cells, tissues and ultimately the whole organism. In vertebrate organisms, this begins at conception from the first steps in blastocyst formation, gastrulation, germ layer differentiation, and organogenesis to a continuum of embryonic, fetal, adolescent, adult, and geriatric stages. Tales of the "fountain of youth" and songs of being "forever young" are dominant ideas informing us that growing old is something science should strive to counteract. Here, we discuss the normal life stages of the blood system, particularly the historical recognition of its importance in the early growth stages of vertebrates, and what this means with respect to progressive gain and loss of hematopoietic function in the adult.

Indexed as

HematopoiesisAgingAnimalsHematopoietic Stem CellsHumansagingdevelopmentfatehematopoiesishemogenic endothelial cell

Identifiers

PMID38439688
PMCPMC11586595
OpenAlexW4392462852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.