Evidence map›Paper›PMID 38439086›Full record

ReviewItalian journal of pediatrics2024

Fatal food anaphylaxis in adults and children.

Elio Novembre, Mariannita Gelsomino, Lucia Liotti, Simona Barni, Francesca Mori, Mattia Giovannini, Carla Mastrorilli, Luca Pecoraro, Francesca Saretta, Riccardo Castagnoli and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in Italian journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Predictors of Fatal Anaphylaxis: A Systematic Review.International archives of allergy and immunology · 2026
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Food allergy and anaphylaxis in a university campus dining program.The journal of allergy and clinical immunology. Global · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. IgE and non-IgE-mediated pathways in anaphylaxis.Seminars in immunopathology · 2025
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Legume Allergens Pea, Chickpea, Lentil, Lupine and Beyond.Current allergy and asthma reports · 2024
    Review
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 2 countries.

Elio NovembreAllergy Unit, Meyer Children's Hospital IRCCS, Florence, 50139, Italy.
Mariannita GelsominoDepartment of Life Sciences and Public Health, Pediatric Allergy Unit, University Foundation Policlinico Gemelli IRCCS Catholic University of the Sacred Heart, Rome, Italy. mariannita.gelsomino@gmail.com.ORCID http://orcid.org/0000-0003-0778-1121
Lucia LiottiDepartment of Mother and Child Health, Pediatric Unit, Salesi Children's Hospital, Ancona, 60123, Italy.
Simona BarniAllergy Unit, Meyer Children's Hospital IRCCS, Florence, 50139, Italy.
Francesca MoriAllergy Unit, Meyer Children's Hospital IRCCS, Florence, 50139, Italy.
Mattia GiovanniniAllergy Unit, Meyer Children's Hospital IRCCS, Florence, 50139, Italy.
Carla MastrorilliPediatric Hospital Giovanni XXIII, Pediatric and Emergency Department, AOU Policlinic of Bari, Bari, 70126, Italy.
Luca PecoraroDepartment of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Pediatric Unit, University of Verona, Verona, 37126, Italy.
Francesca SarettaPediatric Department, Latisana-Palmanova Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, 33100, Italy.
Riccardo CastagnoliDepartment of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, 27100, Italy.
Stefania ArasiTranslational Research in Pediatric Specialties Area, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Rome, 00165, Italy.
Lucia CaminitiDepartment of Pediatrics, Allergy Unit, AOU Policlinico Gaetano Martino, Messina, 98124, Italy.
Angela KlainDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, 80138, Italy.
Michele Miraglia Del GiudiceDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, 80138, Italy.
Meyer Children's Hospital · ITUniversity of Campania "Luigi Vanvitelli" · ITAgostino Gemelli University Polyclinic · ITAzienda Ospedaliera Universitaria Policlinico "G. Martino" · ITBambino Gesù Children's Hospital · ITOspedale di Latisana · ITOspedale Pediatrico Giovanni XXIII · ITUniversity of Pavia · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anaphylaxis is a life-threatening reaction characterized by the acute onset of symptoms involving different organ systems and requiring immediate medical intervention. The incidence of fatal food anaphylaxis is 0.03 to 0.3 million/people/year. Most fatal food-induced anaphylaxis occurs in the second and third decades of life. The identified risk factors include the delayed use of epinephrine, the presence of asthma, the use of recreational drugs (alcohol, nicotine, cannabis, etc.), and an upright position. In the United Kingdom (UK) and Canada, the reported leading causal foods are peanuts and tree nuts. In Italy, milk seems to be the most common cause of fatal anaphylaxis in children < 18 years. Fatal food anaphylaxis in Italian children and adolescents almost always occurs outside and is characterized by cardiorespiratory arrest; auto-injectable adrenaline intramuscular was available in few cases. Mortality from food anaphylaxis, especially in children, is a very rare event with stable incidence, but its risk deeply impacts the quality of life of patients with food allergy and their families. Prevention of fatal food anaphylaxis must involve patients and their families, as well as the general public, public authorities, and patients' associations.

Indexed as

AnaphylaxisAsthmaAdolescentAdultArachisChildEpinephrineHumansQuality of LifeEpinephrineDrug allergyEpinephrineFatal anaphylaxisFood allergyPrevention

Identifiers

PMID38439086
PMCPMC10913226
OpenAlexW4392620615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.