ArticleBMC infectious diseases2024
Antimicrobial resistance patterns, virulence genes, and biofilm formation in enterococci strains collected from different sources.
Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The global prevalence of biofilm-forming Enterococcus faecalis in clinical isolates: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Advancing infection therapy: the role of novel menthol-based antimicrobials.Journal of enzyme inhibition and medicinal chemistry · 2026Article
- Pan-genome analysis reveals the triangle mechanisms of antibiotic resistance, pathogenicity, and biofilm formation in Enterococcus faecalis.Molecular genetics and genomics : MGG · 2026Article
- Dual therapeutic potential of bacteriocin Basin from Bacillus halophilus: attenuation of Enterococcus faecalis virulence gene expression and cytotoxic activity against KB (HeLa-Derived) cells.Molecular biology reports · 2026Article
- Pediococcus acidilactici JUFB as a probiotic antibiofilm adjunct against Enterococcus faecalis in persistent endodontic infections.Antonie van Leeuwenhoek · 2026Article
- Phenotypic and Genotypic Characterization ofBiology · 2026Article
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- Cationic biocide susceptibility and tolerance-associated genes in clinical, environmental, and commensal Enterococcus isolates.Scientific reports · 2026Article
- Enhanced antibiofilm and gene-suppressive effects of cinnamon nanoemulsion against multidrug-resistant Enterococcus faecalis.Molecular biology reports · 2026Article
- Tracking persistent and resistant Enterococcus faecalis and E. faecium from farm to fork: biofilm-linked risks in antibiotic resistance of isolates.Veterinary research communications · 2026Article
- Host-Associated Biofilms:Microorganisms · 2025Review
- Genome analysis reveals a biased distribution of virulence and antibiotic resistance genes in the genusApplied and environmental microbiology · 2025Article
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- Comparative analysis of antibiotic resistance and biofilm formation inFEMS microbes · 2025Article
- Significant changes in gut microbiota and SCFAs among patients with newly diagnosed acute myeloid leukemia.Frontiers in microbiology · 2025Article
- Chemical Composition and Antibacterial Effect of Clove and Thyme Essential Oils on Growth Inhibition and Biofilm Formation ofAntibiotics (Basel, Switzerland) · 2024Article
- A first study of meat-borne enterococci from butcher shops: prevalence, virulence characteristics, antibiotic resistance and clonal relationship.Veterinary research communications · 2024Article
- Article
- Combinatory Effect of Nitroxoline and Gentamicin in the Control of Uropathogenic Enterococci Infections.Antibiotics (Basel, Switzerland) · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, antibiotic-resistant strains of Enterococcus are considered to be one of the critical health challenges globally. This study aimed to investigate the antibiotic susceptibility pattern, biofilm formation capacity, and virulence genes of enterococci isolated from different sources.
methodsIn this cross-sectional study, environmental and fecal samples were collected from the hospital environment, volunteers, and hospital staff from October 2018 to August 2019. The isolates were identified by morphological and biochemical tests (gram staining, catalase, bile resistance, esculin hydrolysis, carbohydrate fermentation, growth in 6.5% NaCl, Pyrrolidonyl arylamidase, arginine dehydrolase), and PCR for ddl gene. An antimicrobial susceptibility test was performed by the standard disk agar diffusion method according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Quantitative microplate assays were used to assess biofilm production. The bacterial DNAs were extracted by alkaline lysis method and polymerase chain reaction technique was used detect the esp, ace, and efaA virulence genes.
resultsOut of 145 isolates, 84 (57.9%) were identified as E. faecalis and 61 (42.1%) as E. faecium. Resistance to kanamycin and quinupristin-dalfopristin was 82.1% (69/84) and 85.7% (72/84), respectively, in E. faecalis isolates. Out of 61 E. faecalis isolates, 38 (62.4%) were resistant to kanamycin. Among the E. faecalis isolates, esp was the most dominant virulence gene (73.80%), followed by efaA, and ace, which were detected in 60.71%, and 30.95% isolates, respectively. In total, 68.27% of the strains were biofilm producers. Further, esp and efaA genes were more frequently found among E. faecalis strains with moderate and strong biofilm biomass.
conclusionsAccording to the findings of our study, enterococci strains isolated from different samples possess distinctive patterns of virulence genes. The esp, ace, and efaA genes were more prevalent among E. faecalis than E. faecium. Besides, the high level antibiotic resistance of normal flora and environmental enterococci strains is alarming the researchers.
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