Evidence map›Paper›PMID 38438978›Full record

SynthesisBMC anesthesiology2024

Effectiveness of tranexamic acid in burn patients undergoing surgery - a systematic review and meta-analysis.

Joeri Slob, Rolf K Gigengack, Margriet E van Baar, Stephan A Loer, Seppe S H A Koopman, Cornelis H van der Vlies

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC anesthesiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Joeri Slob *Burn Center Rotterdam, Maasstadweg 21, Rotterdam, 3079 DZ, The Netherlands. slobj@maasstadziekenhuis.nl.
Rolf K Gigengack *Burn Center Rotterdam, Maasstadweg 21, Rotterdam, 3079 DZ, The Netherlands.
Margriet E van BaarBurn Center Rotterdam, Maasstadweg 21, Rotterdam, 3079 DZ, The Netherlands.
Stephan A LoerDepartment of Anaesthesiology, Amsterdam UMC, Location VU Medical Center, Amsterdam, The Netherlands.
Seppe S H A KoopmanDepartment of Anaesthesiology, Maasstad Hospital, Rotterdam, The Netherlands.
Cornelis H van der VliesBurn Center Rotterdam, Maasstadweg 21, Rotterdam, 3079 DZ, The Netherlands.
Amsterdam UMC Location Vrije Universiteit Amsterdam · NLMaasstad Ziekenhuis · NLAssociation of Dutch Burn Centres · NLErasmus MC · NL

Funding

Nederlandse Brandwonden Stichting 19.102
6 · The paper itself

Abstract

backgroundReducing blood loss during excisional surgery in burn patients remains a challenge. Tranexamic acid during surgery can potentially reduce blood loss. The use of tranexamic acid during excisional surgery in burn patients has recently been described in a review and meta-analysis. However, quality assessment on studies included was not performed and this review did not apply independent reviewers. Quality assessment of studies investigating the effectiveness of tranexamic acid in burn patients is crucial before concusions can be drawn. Therefore, we conducted a systematic review and meta-analysis of the literature investigating the effectiveness of tranexamic acid in burn patients undergoing surgery.

methodsA systematic review and meta-analysis of the literature was conducted. The study was pre-registered in PROSPERO database (CRD42023396183).

resultsFive studies including two randomised controlled trials (RCTs) with a total of 303 patients were included. Risk of bias of the included studies was moderate to high. Individual results of the studies were heterogeneous. In three studies of moderate quality the administration of tranexamic acid resulted in a reduction of blood loss per unit excised area, accounting as moderate level of evidence. In two low-quality studies and one moderate quality study the administration of tranexamic acid resulted in a reduction of transfused packed Red Blood Cells (pRBC's), accounting for moderate level of evidence. Postoperative haemoglobin levels were higher after tranexamic acid administration in one study, accounting for insufficient evidence. Meta-analysis pooling overall blood loss from two separate RCTs failed to detect a statistically significant reduction. Substantial heterogeneity was observed.

conclusionsModerate level of evidence indicates that tranexamic acid reduces blood loss per unit of excised area and transfusion of packed Red Blood Cells. Results indicate that tranexamic acid can be beneficial in burn patients undergoing surgery. More high-quality research is needed to confirm these results. Future studies should focus on the dosing of tranexamic acid, the administration approaches, and even consider combining these approaches.

trial registrationPROSPERO: CRD42023396183.

Indexed as

BurnsTranexamic AcidDatabases, FactualHumansPostoperative PeriodQualitative ResearchRandomized Controlled Trials as TopicTranexamic AcidBurnsHaemorrhageTranexamic Acid

Identifiers

PMID38438978
PMCPMC10910692
OpenAlexW4392372233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.