Ideal adaptive control in biological systems: an analysis of

Akram Ashyani, Yu-Heng Wu, Huan-Wei Hsu, Torbjörn E M Nordling

Abstract read

In one paragraph

Article in BMC bioinformatics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Akram AshyaniDepartment of Mechanical Engineering, National Cheng Kung University, No. 1 University Rd., Tainan, 701, Taiwan.

Yu-Heng WuDepartment of Mechanical Engineering, National Cheng Kung University, No. 1 University Rd., Tainan, 701, Taiwan.

Huan-Wei HsuDepartment of Mechanical Engineering, National Cheng Kung University, No. 1 University Rd., Tainan, 701, Taiwan.

Torbjörn E M NordlingDepartment of Mechanical Engineering, National Cheng Kung University, No. 1 University Rd., Tainan, 701, Taiwan. torbjorn.nordling@nordlinglab.org.

Funding

Ministry of Science and Technology, Taiwan 105-2218-E-006-016-MY2National Science and Technology Council 111-2221-E-006-186

6 · The paper itself

Abstract

backgroundDynamical compensation (DC) provides robustness to parameter fluctuations. As an example, DC enables control of the functional mass of endocrine or neuronal tissue essential for controlling blood glucose by insulin through a nonlinear feedback loop. Researchers have shown that DC is related to the structural unidentifiability and the

resultsWe initiate our analysis by introducing a simplified two-dimensional dynamical model with DC, fostering experimentation and understanding of the system's behavior. We explore the system's behavior with time-varying input and disturbance signals, with a focus on illustrating the system's

conclusionsWe show that DC can be seen as a case of ideal adaptive control since the system is invariant to the compensated parameter.

Indexed as

InsulinResearch DesignEmpirical ResearchUncertaintyInsulinAdaptive proportional-integral feedbackDynamical compensation propertyOrdinary differential equations

Identifiers

PMID38438950

DOI10.1186/s12859-024-05718-5

PMCPMC10913207

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.