ArticleGenome biology2024
Early-life ruminal microbiome-derived indole-3-carboxaldehyde and prostaglandin D2 are effective promoters of rumen development.
Article in Genome biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 21 citations in OpenAlex.
- Bidirectional regulation of gut microbiota and young ruminant host: implications for intestinal development and mucosal immunity.Journal of animal science and biotechnology · 2026Review
- Fermented feed-rumen microbiota axis mediates goat kid growth via microbial amino acid synthesis and ruminal epithelial energy metabolism.NPJ biofilms and microbiomes · 2026Article
- Harnessing the early-life gut microbiome for sustainable ruminant production.Animal microbiome · 2026Review
- Rumen microbiota modulates metabolic stress in high-yield dairy cows: insights from early to peak lactation.Microbiome · 2026Article
- Maternal undernutrition inhibits fetal rumen development: novel miRNA-736-mediated dual targeting of E2F2 and MYBL2 in sheep.Journal of animal science and biotechnology · 2026Article
- Review
- D-serine supplementation is associated with mucosal-prioritized rumen development and propionate-enriched fermentation with selective microbial shifts in pre-weaning Hu lambs.Frontiers in microbiology · 2026Article
- Bidirectional microbial regulation by tyrosine metabolism enhances palmatine-mediated colitis protection.Gut microbes · 2025Article
- Effects of Different Feeding Methods on Growth Performance, Enzyme Activity, Rumen Microbial Diversity and Metabolomic Profiles in Yak Calves.Microorganisms · 2025Article
- Whole-genome sequencing GWAS reveals bovine genomic effects on enteric methane emissions in beef cattle.Scientific reports · 2025Article
- Gut microbiome-derived indole-3-carboxaldehyde promotes intestinal development via AHR-NRF2 signaling in the early-life of chicks.Microbiome · 2025Article
- Nanozymes modulate probiotic tryptophan metabolism to prevent Salmonella infection in mammalian models.Nature microbiology · 2025Article
- Transcriptomic profiling of rumen epithelium, liver, and muscle reveals tissue-specific gene expression patterns in Hu sheep.BMC genomics · 2025Article
- Unveiling novel antimicrobial peptides from the ruminant gastrointestinal microbiomes: A deep learning-driven approach yields an anti-MRSA candidate.Journal of advanced research · 2025Article
- Altered ruminal microbiome tryptophan metabolism and their derived 3-indoleacetic acid inhibit ruminal inflammation in subacute ruminal acidosis goats.Microbiome · 2025Article
- Article
- The expression pattern of butyric acid transporter in the large intestine with growth and development of suckling lambs.Animal bioscience · 2025Article
- Deterministic succession patterns in the rumen and fecal microbiome associate with host metabolic shifts in peripartum dairy cattle.GigaScience · 2025Article
- Adaptive survival strategies of rumen microbiota with solid diet deficiency in early life cause epithelial mitochondrial dysfunction.The ISME journal · 2025Article
- The long-term straw return resulted in significant differences in soil microbial community composition and community assembly processes between wheat and rice.Frontiers in microbiology · 2025Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe function of diverse ruminal microbes is tightly linked to rumen development and host physiology. The system of ruminal microbes is an excellent model to clarify the fundamental ecological relationships among complex nutrient-microbiome-host interactions. Here, neonatal lambs are introduced to different dietary regimes to investigate the influences of early-life crosstalk between nutrients and microbiome on rumen development.
resultsWe find starchy corn-soybean starter-fed lambs exhibit the thickest ruminal epithelia and fiber-rich alfalfa hay-fed lambs have the thickest rumen muscle. Metabolome and metagenome data reveal that indole-3-carboxaldehyde (3-IAld) and prostaglandin D2 (PGD2) are the top characteristic ruminal metabolites associated with ruminal epithelial and muscular development, which depend on the enhanced ruminal microbial synthesis potential of 3-IAld and PGD2. Moreover, microbial culture experiment first demonstrates that Bifidobacterium pseudolongum is able to convert tryptophan into 3-IAld and Candida albicans is a key producer for PGD2. Transcriptome sequencing of the ruminal epithelia and smooth muscle shows that ruminal epithelial and muscular development is accompanied by Wnt and Ca
conclusionsThis study demonstrates that early-life ruminal microbiome-derived 3-IAld and PGD2 are effective promoters of rumen development, which enhances our understanding of nutrient-microbiome-host interactions in early life.
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