Evidence map›Paper›PMID 38438730›Full record

ArticleCEN case reports2024

Lipoprotein glomerulopathy: a rare cause of steroid-resistant nephrotic syndrome in a child.

Kinnari Vala, Kanisha Shah, Shahenaz Kapadia, Mahipal Khandelwal, Amit Jojera, Shailesh Soni, Ashka Prajapati, Anshuman Saha

Open access · greenAbstract readCase Reports
In one paragraph

Article in CEN case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kinnari ValaDepartment of Pediatric Nephrology and Pediatric Renal Transplantation, Institute of Kidney Diseases and Research Center and Dr. H L Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Gujarat University of Transplantation Sciences, Ahmedabad, India. kbvala@gmail.com.ORCID 0000-0003-3426-5675
Kanisha ShahDepartment of Pediatric Nephrology and Pediatric Renal Transplantation, Institute of Kidney Diseases and Research Center and Dr. H L Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Gujarat University of Transplantation Sciences, Ahmedabad, India.
Shahenaz KapadiaDepartment of Pediatric Nephrology and Pediatric Renal Transplantation, Institute of Kidney Diseases and Research Center and Dr. H L Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Gujarat University of Transplantation Sciences, Ahmedabad, India.
Mahipal KhandelwalB.T.Savani Hospital, Rajkot, India.
Amit JojeraDepartment of Pathology, Muljibhai Patel Urological Hospital, Nadiad, India.
Shailesh SoniDepartment of Pathology, Muljibhai Patel Urological Hospital, Nadiad, India.
Ashka PrajapatiNeuberg Center for Genomic Medicine, Ahmedabad, India.
Anshuman SahaDepartment of Pediatric Nephrology and Pediatric Renal Transplantation, Institute of Kidney Diseases and Research Center and Dr. H L Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Gujarat University of Transplantation Sciences, Ahmedabad, India.
Gujarat University · INMuljibhai Patel Urological Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipoprotein glomerulopathy (LPG) is a rare condition of renal lipidosis characterized by lipoprotein thrombi in glomeruli, an abnormal plasma lipoprotein profile, and a marked increase in serum apolipoprotein E (apo E) levels. It is a monogenic disorder with autosomal dominant inheritance and the average age of presentation is 32 years (4-69 years). It is rare in children. The presentation can be nephrotic syndrome, hematuria, or progressive renal failure. Here we report the first described case of LPG in an Indian 7.5-year-old boy who presented with steroid-resistant nephrotic syndrome with normal renal function. A renal biopsy was suggestive of lipoprotein glomerulopathy. The detection of a pathogenic variant in apo E, Kyoto type, by exome sequencing, confirmed the diagnosis of lipoprotein glomerulopathy. Complete response was achieved with Angiotensin-converting Enzyme inhibitor and fenofibrates.

Indexed as

Nephrotic SyndromeAngiotensin-Converting Enzyme InhibitorsApolipoprotein E2ChildExome SequencingHumansKidney DiseasesKidney GlomerulusMaleTreatment OutcomeAngiotensin-Converting Enzyme InhibitorsApolipoprotein E2apolipoprotein E2 (Kyoto)Apolipoprotein ELipoproteinsNephrotic syndrome

Identifiers

PMID38438730
PMCPMC11442800
OpenAlexW4392382418

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.