Evidence map›Paper›PMID 38438681›Full record

Trial reportCanadian journal of anaesthesia = Journal canadien d'anesthesie2024

The 90% effective dose of intrathecal hyperbaric bupivacaine for Cesarean delivery under combined spinal-epidural anesthesia in parturients with super obesity: an up-down sequential allocation study.

Hon Sen Tan, Matthew E Fuller, Emily Z Barney, Olga I Diomede, Riley A Landreth, Trung Pham, Samantha M Rubright, Liliane Ernst, Ashraf S Habib

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03781388 (ED90 for Hyperbaric Bupivacaine in Spinal Anesthesia for Cesarean Delivery in Super Obese Parturients), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03781388 phase4completednot on this map

ED90 for Hyperbaric Bupivacaine in Spinal Anesthesia for Cesarean Delivery in Super Obese Parturients

TypeinterventionalSponsorDuke UniversityRan2019 to 2022Enrolled45ConditionsObesity, Morbid, Spinal Anesthesia, Cesarean DeliveryArmsBupivacaine
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Hon Sen TanDepartment of Women's Anaesthesia, KK Women's and Children's Hospital, Singapore, Singapore.
Matthew E FullerDepartment of Anesthesiology, Duke University Medical Center, Duke University, Durham, NC, USA.
Emily Z BarneyDepartment of Anesthesiology, Duke University Medical Center, Duke University, Durham, NC, USA.
Olga I DiomedeDepartment of Anesthesiology and Perioperative Medicine, Maine Medical Center, Portland, OR, USA.
Riley A LandrethDepartment of Anesthesiology, University of North Carolina, Chapel Hill, NC, USA.
Trung PhamAssociated Anesthesiologists Inc., Tulsa, OK, USA.
Samantha M RubrightDepartment of Anesthesiology, University of Utah, Salt Lake City, UT, USA.
Liliane ErnstDivision of Women's Anesthesia, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
Ashraf S HabibDivision of Women's Anesthesia, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA. ashraf.habib@duke.edu.ORCID 0000-0002-6980-1856
Duke Medical Center · USAmerican Society of Anesthesiologists · USDuke University · USKK Women's and Children's Hospital · SGMaine Medical Center · USUniversity of North Carolina at Chapel Hill · USUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the 90% effective dose (ED

methodsWe enrolled parturients with BMI ≥ 50 kg·m

resultsWe enrolled 45 parturients and included 42 in the analysis. All doses achieved a T6 level within ten minutes, and the primary outcome occurred in 0/1 (0%) of the 9.75-mg doses, 2/3 (67%) of the 10.5-mg doses, 21/27 (78%) of the 11.25-mg doses, and 11/11 (100%) of the 12-mg doses. The ED

conclusionThe estimated ED STUDY REGISTRATION: ClinicalTrials.gov (NCT03781388); first submitted 18 December 2018.

Indexed as

Anesthesia, EpiduralAnesthesia, ObstetricalAnesthesia, SpinalAnesthetics, LocalBupivacaineDouble-Blind MethodFemaleFentanylHumansMorphineObesityPregnancyAnesthetics, LocalBupivacaineFentanylMorphinebupivacainecombined spinal epiduralneuraxialspinalsuper obesity

Identifiers

PMID38438681
OpenAlexW4392384613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.