Evidence map›Paper›PMID 38438636›Full record

Observational studyActa neurologica Belgica2024

From periphery to center, untold story of pure neuritic leprosy: an electrophysiological study.

Sanjeev Kumar Bhoi, Yuvraj Lahre, Menka Jha, Suprava Naik, Suvendu Purkait, Priyanka Samal, Gautom Kumar Saharia, Mukesh Kumar, Pritimayee Behera

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Acta neurologica Belgica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sanjeev Kumar BhoiDepartment of Neurology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, 751019, India. sanjeev_bhoi@rediffmail.com.ORCID http://orcid.org/0000-0002-5192-7637
Yuvraj LahreDepartment of Neurology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, 751019, India.
Menka JhaDepartment of Neurology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, 751019, India.
Suprava NaikDepartment of Radiodiagnosis, All India Institute of Medical Sciences, Bhubaneswar, Odisha, 751019, India.
Suvendu PurkaitDepartment of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, 751019, India.
Priyanka SamalDepartment of Neurology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, 751019, India.
Gautom Kumar SahariaDepartment of Biochemistry, All India Institute of Medical Sciences, Bhubaneswar, Odisha, 751019, India.
Mukesh KumarDepartment of Neurology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, 751019, India.
Pritimayee BeheraDepartment of Neurology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, 751019, India.
All India Institute of Medical Sciences Bhubaneswar · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPure neuritic leprosy (PNL) is uncommon form of leprosy involving peripheral nerves. Some isolated case reports have shown imaging changes in the central nervous system (CNS) and also impairment in visual evoked potential (VEP), somatosensory evoked potential (SSEP) and brain stem auditory-evoked potentials (BAEPs) parameters in PNL, but there is lack of large study. This prospective observational study evaluates impairment in these central conduction studies among PNL patients.

methodsWe screened patients with leprosy presenting with features of neuropathy and/or thickened nerves. Patients with bacilli-positive nerve biopsies were included in the study and subjected to routine tests along with nerve conduction study (NCS), VEP, tibial SSEP and BAEPs. Parameters of these studies were analyzed based on data from previous studies.

resultsOf 76 patients screened for PNL 49 had positive findings in biopsy. Most of patients were male and mean age group was 46.35 ± 15.35 years. Mononeuritis multiplex was most common NCS pattern in 46.93% (23/49) patients. We found abnormal VEP in 13 out of 35 patients (37.14%). Similarly abnormal SSEP and BAEPs among 42.85% and 40% patients respectively. DISCUSSION: This study shows that in PNL significant number of patients have subclinical CNS involvement. Exact pathophysiology of CNS involvement is not known till now but study of VEP, SSEP and BAEPs parameter may help in early diagnosis of PNL.

Indexed as

Evoked Potentials, SomatosensoryAdultAgedEvoked Potentials, Auditory, Brain StemEvoked Potentials, VisualFemaleHumansLeprosyMaleMiddle AgedNeural ConductionNeuritisProspective StudiesBAEPsHansen’s diseaseMycobacterium lepraePure neuritic leprosySSEPVEP

Identifiers

PMID38438636
OpenAlexW4392367237

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.